Joint Reconstruction of Activity and Attenuation in Time-of-Flight PET: A Quantitative Analysis

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ahmadreza RezaeiJohan Nuyts

Abstract

Methods for joint activity reconstruction and attenuation reconstruction of time-of-flight (TOF) PET data provide an effective solution to attenuation correction when no (or incomplete or inaccurate) information on attenuation is available. One of the main barriers limiting use of these methods in clinical practice is their lack of validation in a relatively large patient database. In this contribution, we aim to validate reconstruction performed with maximum-likelihood activity reconstruction and attenuation registration (MLRR) in a whole-body patient dataset. Furthermore, a partial validation (because the scale problem of the algorithm is avoided for now) of reconstruction performed with maximum-likelihood activity and attenuation (MLAA) is also provided. We present a quantitative comparison between these 2 methods of joint reconstruction and the current clinical gold standard, maximum-likelihood expectation maximization (MLEM) with CT-based attenuation correction. Methods: The whole-body TOF PET emission data of each patient dataset were processed as a whole to reconstruct an activity volume covering all the acquired bed positions, helping reduce the problem of a scale per bed position in MLAA to a global scale for the entir...Continue Reading

References

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Feb 1, 2012·Physics in Medicine and Biology·Michel DefriseJohan Nuyts
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Apr 25, 2014·IEEE Transactions on Medical Imaging·Ahmadreza RezaeiJohan Nuyts
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Feb 7, 2017·Physics in Medicine and Biology·Harshali BalMichael E Casey
Jul 25, 2017·Physics in Medicine and Biology·Ahmadreza RezaeiJohan Nuyts

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Citations

Jan 15, 2020·EJNMMI Physics·Pablo García-Pérez, Samuel España
Jul 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Hossein ArabiHabib Zaidi
Mar 7, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mingzan ZhuangHabib Zaidi
May 18, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Isaac ShiriHabib Zaidi
Feb 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yasheng ChenHongyu An
Feb 3, 2021·Seminars in Nuclear Medicine·Patrick Dupont
Dec 19, 2020·Physics in Medicine and Biology·Steven R MeikleJoyita Dutta
Mar 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Hossein ArabiHabib Zaidi
Apr 14, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ahmadreza RezaeiJohan Nuyts
Jul 11, 2021·Seminars in Nuclear Medicine·Yu-Jung Tsai, Chi Liu
Sep 5, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hossein Arabi, Habib Zaidi

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