Journey into Bone Models: A Review

Genes
Julia ScheinpflugFrank Schulze

Abstract

Bone is a complex tissue with a variety of functions, such as providing mechanical stability for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To fulfil these diverse roles in the human body, bone consists of a multitude of different cells and an extracellular matrix that is mechanically stable, yet flexible at the same time. Unlike most tissues, bone is under constant renewal facilitated by a coordinated interaction of bone-forming and bone-resorbing cells. It is thus challenging to recreate bone in its complexity in vitro and most current models rather focus on certain aspects of bone biology that are of relevance for the research question addressed. In addition, animal models are still regarded as the gold-standard in the context of bone biology and pathology, especially for the development of novel treatment strategies. However, species-specific differences impede the translation of findings from animal models to humans. The current review summarizes and discusses the latest developments in bone tissue engineering and organoid culture including suitable cell sources, extracellular matrices and microfluidic bioreactor systems. With available technology in mind, a best possible bone model...Continue Reading

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Citations

Jul 3, 2020·Frontiers in Bioengineering and Biotechnology·Giulia MontagnaLouis Gerstenfeld
Sep 19, 2019·Biotechnology and Bioengineering·Mikhael Hadida, David Marchat
May 8, 2020·Advanced Healthcare Materials·Elena StengelinSebastian Seiffert
Oct 6, 2020·Frontiers in Bioengineering and Biotechnology·Hossein BahmaeeFrederik Claeyssens
Oct 30, 2020·International Journal of Molecular Sciences·Alexandra Damerau, Timo Gaber
Jan 16, 2021·Current Osteoporosis Reports·Sana AnsariSandra Hofmann
Feb 4, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Moritz PfeiffenbergerAnnemarie Lang
Aug 23, 2020·Journal of Biomechanics·Fatemeh Mokhtari-JafariMohammad Mehdi Dehghan
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Durgalakshmi DhinasekaranBalakumar Subramaniam
Jul 3, 2021·Biomedicines·Moritz PfeiffenbergerTimo Gaber
Jul 25, 2021·International Journal of Molecular Sciences·Anne BernhardtMichael Gelinsky
Apr 1, 2021·Stem Cells·Laleh ShariatiAbbas Amini

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Methods Mentioned

BETA
bioprinting
chips
chip

Software Mentioned

LIFT

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Bioreactors (ASM)

Bioreactors are important devices or systems that utilize living cells or enzymes for a chemical process. These devices carefully control and monitor the environment factors such as pH, nutrients level, and temperature, which can affect the yield in a given process. Discover the latest research here.

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