JP-8 jet fuel exposure potentiates tumor development in two experimental model systems

Toxicology and Industrial Health
D T HarrisMark L Witten

Abstract

The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion of two immunosuppressive agents; namely, interleukin-10 (IL-10) and prostaglandin E2 (PGE2). Thus, it was of interest to determine if jet fuel exposure might promote tumor growth and metastasis. The syngeneic B16 tumor model was used for these studies. Animals were injected intravenously with tumor cells, and lung colonies were enumerated. Animals were also examined for metastatic spread of the tumor. Mice were either exposed to 1000 mg/m3 JP-8 (1 h/ day) for 7 days before tumor injection or were exposed to JP-8 at the time of tumor injection. All animals were killed 17 days after tumor injection. In the present study, JP8 exposure potentiated the growth and metastases of B16 tumors in an animal model. Exposure of mice to JP-8 for 1 h/day before tumor induction resulted in an approximately 8.7-fold increase in tumors, whereas those mice exposed to JP8 at the time of tumor induction had a 5.6-fold increase in tumor ...Continue Reading

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Citations

Sep 14, 2013·Journal of Toxicology and Environmental Health. Part a·Kimber L WhiteVanessa L Peachee
Mar 16, 2011·Toxicology and Industrial Health·Jianhua W HilgaertnerDavid T Harris
Mar 18, 2010·Toxicology Mechanisms and Methods·Jay S HanasJames R Hocker

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