JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer through reduction of STAT3 phosphorylation

The American Journal of Chinese Medicine
Jia QiJian Zhang

Abstract

Breast cancer (BC) is the most frequently diagnosed type of cancer all over the world. Angiogenesis, a physiological or pathological process characterized by the sprouting of new blood vessels from existing vessels, plays a vital role in tumor nutrition. In this work, we used JSI-124 (Cucurbitacin I), a selective JAK/STAT3 signaling pathway inhibitor, to investigate the role of STAT3 in tumor angiogenesis of a human BC cell line in vitro. JSI-124 inhibited cell viability, proliferation, adhesion, migration and tube formation of a human BC cell line MDA-MB-468. After transfection with pMXs-Stat3C, a dominant active mutant, the inhibitory effects of JSI-124 on MDA-MB-468 were abolished. Furthermore, JSI-124 reduced the phosphorylation of STAT3. These results suggested that JSI-124 inhibited tumor angiogenesis of the human BC cell line in vitro through the reduction of STAT3 phosphorylation. In addition, JSI-124 could reduce VEGF transcription and secretion, suggesting that JSI-124 is also involved in the inhibition of the VEGF autocrine loop in the tumor microenvironment.

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Citations

May 24, 2016·The International Journal of Biochemistry & Cell Biology·Sonam SinhaSyed Musthapa Meeran
Dec 19, 2016·Biochemical and Biophysical Research Communications·Lulu CuiXiaochun Wan
Mar 10, 2017·Journal of Pharmaceutical and Biomedical Analysis·Giovana Maria Lanchoti FioriNorberto Peporine Lopes
Jul 1, 2017·The American Journal of Chinese Medicine·Yan-Mei ShuiJian-Li Gao
Nov 25, 2016·Experimental and Therapeutic Medicine·Li LiWanzhuo Xie
Aug 3, 2017·BMC Complementary and Alternative Medicine·Xin RuiXiao-Ming Xu
Feb 18, 2020·Molecular Biology Reports·Alexandria TurnerChristopher J Scarlett
Apr 18, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Abedul HaqueArm R Amin

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