Juggling jobs: roles and mechanisms of multifunctional protease inhibitors in plants

The New Phytologist
Friederike M Grosse-Holz, Renier A L van der Hoorn

Abstract

Multifunctional protease inhibitors juggle jobs by targeting different enzymes and thereby often controlling more than one biological process. Here, we discuss the biological functions, mechanisms and evolution of three types of multifunctional protease inhibitors in plants. The first type is double-headed inhibitors, which feature two inhibitory sites targeting proteases with different specificities (e.g. Bowman-Birk inhibitors) or even different hydrolases (e.g. α-amylase/protease inhibitors preventing both early germination and seed predation). The second type consists of multidomain inhibitors which evolved by intragenic duplication and are released by processing (e.g. multicystatins and potato inhibitor II, implicated in tuber dormancy and defence, respectively). The third type consists of promiscuous inhibitory folds which resemble mouse traps that can inhibit different proteases cleaving the bait they offer (e.g. serpins, regulating cell death, and α-macroglobulins). Understanding how multifunctional inhibitors juggle biological jobs increases our knowledge of the connections between the networks they regulate. These examples show that multifunctionality evolved independently from a remarkable diversity of molecular mech...Continue Reading

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Citations

Mar 3, 2018·International Journal of Molecular Sciences·Emma L Thomas, Renier A L van der Hoorn
Mar 7, 2018·Plant Biotechnology Journal·Friederike Grosse-HolzRenier A L van der Hoorn
Feb 6, 2019·Journal of Experimental Botany·Maja CohenRobert Fluhr
Feb 26, 2019·Journal of Experimental Botany·Álvaro Daniel Fernández-FernándezSimon Stael
Jan 10, 2018·Frontiers in Plant Science·Ekaterina V SheshukovaYuri L Dorokhov
Jul 26, 2018·Frontiers in Plant Science·Ana ArnaizM E Santamaria
Feb 12, 2017·Biotechnology Letters·Shazia RehmanTariq Mahmood
Jan 21, 2017·PloS One·Nerea MatamalaBeatriz Martinez-Delgado
Jun 22, 2019·Journal of Experimental Botany·Simon StaelMoritz K Nowack
Mar 20, 2019·International Journal of Molecular Sciences·Marina ClementeVíctor A Ramos-Duarte
Aug 14, 2019·Scientific Reports·M Rafiq IslamI Sakif Islam
Jan 27, 2021·The Journal of Parasitology·Helen Silva RibeiroLívio Martins Costa-Junior
Feb 2, 2020·Plant Science : an International Journal of Experimental Plant Biology·Juliana CotabarrenWalter David Obregón
Jan 23, 2021·International Journal of Molecular Sciences·Mohamed Amine JmelMichalis Kotsyfakis
Mar 2, 2021·Transgenic Research·J F BuyelL Bortesi
Sep 5, 2020·European Journal of Medicinal Chemistry·Clara DavoineLionel Pochet
Feb 16, 2021·Journal of Experimental Botany·Ying ChenHannes Vanhaeren
May 12, 2021·Journal of Insect Science·Omaththage P PereraGordon L Snodgrass
Jan 24, 2019·Journal of Natural Products·Junqiao DuDavid J Craik

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