Juguloarterial endothelin-1 gradients after severe traumatic brain injury.

Neurocritical Care
Doris A ChatfieldDavid K Menon

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor and is thought to be responsible for secondary ischemia and vasogenic edema after traumatic brain injury (TBI). Both CSF and plasma concentrations have been shown to be increased after TBI, but there is little evidence to confirm an intracranial site of production. Using paired arterial and jugular venous bulb sampling, we measured arterial and jugular levels of ET-1 and its precursor, big endothelin (Big ET), and calculated juguloarterial (JA) gradients for the first 5 days post-TBI. Arterial levels of both Big ET and ET-1 were maximal on day 1 post-TBI, and decreased thereafter (P < 0.05). Arterial levels of Big ET and ET-1 showed correlation across all 5 days of the study (r(2) = 0.25, P < 0.001). While there was no significant JA gradient for Big ET, significant gradients were observed for ET-1 on days 1-4 post-TBI (P < 0.05). There was no correlation between JA gradients for Big ET and ET-1 (r(2) < 0.1, P > 0.9). These data suggest parenchymal production of ET-1 by brain tissue with spill over into the blood, rather than local intraluminal cleavage of Big ET in the cerebral vasculature. Systemic ET-1 levels and JA gradients of ET-1 were unrelated to the injury severity, APACH...Continue Reading

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Feb 1, 1984·American Journal of Epidemiology·J F KrausL Marshall
Feb 1, 1994·Journal of Neurosurgery·A MarmarouK Demetriadou
Nov 15, 2000·Journal of Cardiovascular Pharmacology·F C BaroneE Shohami
Feb 21, 2002·Journal of Neurotrauma·Edward J GabrielUNKNOWN Brain Trauma Foundation
Aug 24, 2002·Clinical Science·David K MenonAnthony P Davenport
Sep 25, 2003·Surgical Neurology·Todd W VitazChristopher B Shields
Dec 4, 2003·European Journal of Endocrinology·G KirilovA S Alexandrov
Dec 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jörg KleebergJens P Dreier
Sep 30, 2005·Acta neurochirurgica·S KästnerW Deinsberger
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Allison J SutherlandJohn F Fraser
Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Octavio MoldesJosé Castillo
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Matthias Barton, Masashi Yanagisawa

❮ Previous
Next ❯

Citations

May 3, 2016·Progress in Neurobiology·Stéphanie HostenbachJacques De Keyser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.