PMID: 2493644Mar 1, 1989Paper

jun-D: a third member of the jun gene family

Proceedings of the National Academy of Sciences of the United States of America
K RyderD Nathans

Abstract

The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding a third member of the murine jun family, jun-D. The amino acid sequence encoded by jun-D has two extensive regions of homology with the other Jun proteins. One homology region includes the DNA-binding domain and sequences required for dimer formation and interaction with the Fos oncoprotein; the other includes the acidic sequence thought to be involved in gene activation. All three jun mRNAs are present in a variety of murine tissues and cell lines. In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors. Thus, jun-D appears to be regulated differently than c-jun and jun-B.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Aug 18, 1988·Nature·W W LamphI M Verma
Dec 1, 1988·Genes & Development·F J RauscherT Curran
Jul 28, 1988·Nature·P Sassone-CorsiI M Verma
Dec 15, 1988·Nature·T Kouzarides, E Ziff
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y MakiP K Vogt
Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·D NathansK Ryder
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Ryder, D Nathans
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Nov 15, 1983·Journal of Molecular Biology·A M FrischaufN Murray
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D A Goldberg

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Citations

Mar 1, 1996·Journal of Neuroscience Research·M E ShyS S Scherer
May 1, 1997·Journal of Cellular Biochemistry·P S PollackB Goldman
Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Kwon, R G Oshima
Feb 1, 1993·Journal of Cellular Physiology·P SchmiedebergM J Czaja
Nov 1, 1991·Molecular Reproduction and Development·A A AlcivarN B Hecht
Jan 1, 1996·Molecular Biology Reports·R L Eckert, J F Welter
Apr 1, 1994·Neurochemical Research·D F CondorelliA M Giuffrida-Stella
Jul 1, 1991·Somatic Cell and Molecular Genetics·M Shapiro, C A Kozak
Feb 20, 2007·Calcified Tissue International·O Akhouayri, R St-Arnaud
Jul 27, 2005·Histochemistry and Cell Biology·Danko S BatusicGiuliano Ramadori
Jan 1, 1990·Pharmacology & Therapeutics·H J Rahmsdorf, P Herrlich
Mar 1, 1993·Brain Research. Molecular Brain Research·J DemmerW P Tate
Sep 5, 1996·Brain Research. Molecular Brain Research·N S HaqueD J Sirinathsinghji
Aug 11, 1995·Molecular and Cellular Endocrinology·B van der BurgP T van der Saag
May 17, 1996·Molecular and Cellular Endocrinology·D J Autelitano, D R Cohen
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Dec 16, 1992·Biochimica Et Biophysica Acta·S E PlyteJ R Woodgett
Feb 14, 1995·Gene·T YamadaT Nishihara
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H A Armelin
Feb 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C ChiappettaG M Stancel
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·L CicatielloA Weisz
Sep 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·K P NephewS A Khan

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