Junctional adhesion molecule overexpression in Kaposi varicelliform eruption skin lesions - as a possible herpes virus entry site.

North American Journal of Medical Sciences
Ana Maria Abreu-VelezMichael S Howard

Abstract

Herpes simplex virus (HSV) infection of the skin represents a common challenge in dermatology; however, currently the port of viral entry remains obscure. HSV is known to induce an immunoglobulin-binding cell surface receptor in infected cells that utilizes a non-immune mechanism. The replication of HSV in cultured cells is accompanied by the appearance of surface receptors with an affinity for the Fc region of immunoglobulin G. We describe a 43 year old African American male who presented with a generalized rash, including intense pruritus and umbilicated vesiculopustules. The patient had been previously diagnosed and treated for psoriasis with methotrexate and prednisone. Hematoxylin and eosin demonstrated keratinocytes with ballooning degeneration within the epidermis. Direct immunofluorescence (DIF) results resembled the pattern of paraneoplastic pemphigus, with negative indirect immunofluorescence (IIF) results on rat bladder. Immunohistochemistry revealed deposits of the complement membrane attack complex within dermal sweat glands, as well as the presence of herpes simplex virus 1 on the skin. We report a case of Kaposi varicelliform eruption, a cutaneous eruption caused by a virus infecting patients with pre-existing de...Continue Reading

Citations

Jan 12, 2016·Indian Dermatology Online Journal·Bruno FerrariMargarita Larralde
Jun 30, 2018·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Maliha AzmiMuhammed Mubarak

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Methods Mentioned

BETA
biopsies
ELISA
biopsy
enzyme-linked immunosorbent assay

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