Junctional and extrajunctional membrane channels activated by GABA in locust muscle fibres

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
S G Cull-Candy, R Miledi

Abstract

Iontophoretic application of GABA to voltage-clamped locust muscle fibres has demonstrated the presence of both extrajunctional and junctional GABA receptors. Extrajunctional GABA receptors are distinct from extrajunctional glutamate receptors which also occur in these muscle fibres. Inward GABA currents are nonlinearly dependent on membrane potential. Analysis of membrane current noise produced by iontophoretic GABA application shows that for junctional and extrajunctional GABA receptors the mean channel lifetime is 3-4 ms and the single-channel conductance is approximately 22 pS at - 80 mV (T = 21 degrees C). The mean lifetime as previously demonstrated for glutamate-sensitive excitatory channels in locust muscle fibres.

References

Oct 19, 1977·Pflügers Archiv : European journal of physiology·J Dudel
Sep 1, 1978·The Journal of Physiology·C R AndersonR Miledi
May 1, 1979·The Journal of Physiology·R B ClarkP N Usherwood
Aug 10, 1978·Nature·R N McBurney, J L Barker
Feb 1, 1976·The Journal of Physiology·S G Cull-Candy
Aug 1, 1972·The Journal of Physiology·B Katz, R Miledi
Dec 31, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R MilediI Parker
Sep 1, 1980·Pflügers Archiv : European journal of physiology·J DudelH Stettmeier
Mar 1, 1965·The Journal of Physiology·A TAKEUCHI, N TAKEUCHI
Mar 18, 1965·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J DUDEL
May 1, 1965·Journal of Neurophysiology·P N USHERWOOD, H GRUNDFEST

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Citations

Aug 1, 1987·Pflügers Archiv : European journal of physiology·O TalebA Feltz
Feb 1, 1984·Pflügers Archiv : European journal of physiology·W Finger, H Stettmeier
Mar 1, 1991·Neurochemical Research·D B SattelleJ J Rauh
Oct 1, 1996·Molecular Neurobiology·T A Cleland
Jan 1, 1989·Pharmacology & Therapeutics·G A Cottrell, G S Bewick
Jan 1, 1996·Pharmacology & Therapeutics·R H Osborne
Jan 1, 1989·Neuroscience·J C StrahlendorfH K Strahlendorf
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S C Lummis
Feb 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J Kerrison, J E Freschi
Jan 1, 1986·Journal of Toxicology and Environmental Health·I M AbalisA T Eldefrawi
Jun 1, 1985·British Journal of Pharmacology·I R Duce, R H Scott
Aug 22, 1986·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P T Gray, J M Ritchie
Jun 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Constanti, T G Smart
Jan 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D B SattelleJ A David
Jun 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P T GrayJ M Ritchie
Feb 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D J AdamsO P Hamill
Aug 1, 1996·Protein Science : a Publication of the Protein Society·G D SmithW Pangborn
May 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S G Cull-Candy
Apr 1, 1991·The American Journal of Physiology·T NakagawaN Akaike

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