PMID: 8599063Jul 1, 1995Paper

Jungle yellow fever: clinical and laboratorial studies emphasizing viremia on a human case

Revista Do Instituto De Medicina Tropical De São Paulo
E da S NassarA P Travassos da Rosa

Abstract

The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5, 7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglutination Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the ...Continue Reading

References

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Citations

Dec 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter G Jupp, Alan Kemp
Dec 13, 2000·Microbes and Infection·L T Figueiredo
Nov 26, 2010·Journal of Clinical Microbiology·Cristina DomingoMatthias Niedrig
Jul 11, 2008·Reviews in Medical Virology·Brett R Ellis, Alan D T Barrett
Jul 14, 2018·Emerging Microbes & Infections·Cristina DomingoChantal Reusken
Aug 31, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Jean-Philippe Chippaux, Alain Chippaux
May 23, 2019·Memórias do Instituto Oswaldo Cruz·Luciana Vilas Boas CasadioJoão Renato Rebello Pinho

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