Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats

Frontiers in Psychiatry
Alisa R KosheleffSean B Ostlund

Abstract

There is growing evidence that repeated consumption of highly palatable, nutritionally poor "junk food" diets can produce deficits in cognition and behavioral control. We explored whether long-term junk-food diet exposure disrupts rats' ability to make adaptive choices about which foods to pursue based on (1) expected reward value (outcome devaluation test) and (2) cue-evoked reward expectations (Pavlovian-to-instrumental test). Rats were initially food restricted and trained on two distinct response-outcome contingencies (e.g., left press chocolate pellets, and right press sweetened condensed milk) and stimulus-outcome contingencies (e.g., white noise chocolate pellets, and clicker sweetened condensed milk). They were then given 6 weeks of unrestricted access to regular chow alone (controls) or chow and either 1 or 24 h access to junk food per day. Subsequent tests of decision making revealed that rats in both junk-food diet groups were impaired in selecting actions based on either expected food value or the presence of food-paired cues. These data demonstrate that chronic junk food consumption can disrupt the processes underlying adaptive control over food-seeking behavior. We suggest that the resulting dysregulation of food ...Continue Reading

References

Jan 1, 1990·Behavioral and Neural Biology·C E Greenwood, G Winocur
Apr 2, 1999·Psychopharmacology·C J Harmer, G D Phillips
Jun 18, 1999·Behavioural Brain Research·G Winocur, C E Greenwood
Feb 28, 2002·Behavioural Processes·Ruth M. Colwill, Scott M. Triola
Mar 6, 2004·Eating Behaviors·Anita JansenAnne Roefs
Sep 6, 2005·Physiology & Behavior·Ariel Buda-LevinRebecca L Corwin
Sep 29, 2005·Appetite·Rebecca L Corwin
Nov 1, 2005·Neurobiology of Aging·Carol E Greenwood, Gordon Winocur
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B Ostlund, Bernard W Balleine
Mar 4, 2009·Neuropsychology·Richard E BlakesleyMeryl A Butters
Aug 7, 2009·The American Journal of Clinical Nutrition·John R Krebs
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·Scott E KanoskiTerry L Davidson
Jul 6, 2010·Neuropharmacology·Leandro F VendruscoloMartine Cador
Aug 21, 2010·Frontiers in Integrative Neuroscience·Sean B OstlundBernard W Balleine
Nov 26, 2010·Neurobiology of Learning and Memory·I Valladolid-AcebesN Del Olmo
May 10, 2011·Physiology & Behavior·Rebecca L CorwinMary M Boggiano
Aug 19, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew C ShinHans-Rudolf Berthoud
Aug 30, 2011·Lancet·Boyd A SwinburnSteven L Gortmaker
Sep 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sean B Ostlund, Nigel T Maidment
Oct 13, 2011·Behavioral Neuroscience·Matthew D PuhlPatricia S Grigson
Dec 29, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sean B OstlundNigel T Maidment
Jan 15, 2014·Eating Behaviors·Adrian MeuleAndrea Kübler
Apr 4, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Teri M FurlongLaura H Corbit
May 9, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sean B OstlundNigel T Maidment
Sep 16, 2014·Frontiers in Psychology·Amy C ReicheltR F Westbrook
Nov 16, 2014·Advances in Nutrition·Fiona Johnson, Jane Wardle
Mar 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mike J F RobinsonCarrie R Ferrario
Jul 21, 2015·Physiology & Behavior·Shannon E MarwitzSarah N Blythe
Dec 24, 2015·Current Topics in Behavioral Neurosciences·Laura H Corbit, Bernard W Balleine

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Citations

Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Jaume F Lalanza, Eelke M S Snoeren
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kristian LeisegangRalf Henkel
Mar 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zachary Pierce-Messick, Laura H Corbit
Mar 2, 2021·Frontiers in Neuroscience·Linda TsanScott E Kanoski

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