Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Bassem F El-KhodorDani Brunner

Abstract

Serotonin is an important modulator of anxiety and thus drugs that act on this system have frequently been shown to be either anxiogenic or anxiolytic. In addition serotonin has important trophic functions during early development and disruption of serotonin homeostasis is likely to have long-lasting repercussions in the adult. In the present study we examined the contribution of two serotonin receptor subtypes (5HT(1A) and 5HT(1B)) to the pathophysiology of anxiety during development. For this, we have studied homozygous knockout mice lacking the 5HT(1B) receptor and examined the effect of pharmacological manipulations of 5HT(1A) and 5HT(1B) receptors on locomotor activity and emission of ultrasonic vocalization (USV) in 7-8 days old mice. As shown before, drug naïve 5HT(1B) knockout pups showed reduced USV and were hyperactive, in comparison to wild type controls. The administration of RU24969 (a 5HT(1A/1B) agonist) showed a dose-dependent decrease in USV in the wild type and a biphasic effect in the mutants and resulted in dose-dependent increase in activity in the wild type and, to a lesser extent, in the knockouts. The selective 5HT(1A) agonist, 8OH-DPAT, dose-dependently blocked vocalization in both genotypes and also inc...Continue Reading

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Citations

Sep 13, 2007·Molecular Psychiatry·S S Moy, J J Nadler
Apr 23, 2015·Molecular Autism·Valentina MosienkoMarkus Wöhr
Oct 28, 2005·Developmental Psychobiology·Herbert Weiner
Feb 28, 2007·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Semih SeminDilek Guldal
Jan 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lina YangYanli Zhang-James
Jul 30, 2015·Behavioural Pharmacology·Markus WöhrRainer K W Schwarting

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