Juvenile diabetes mellitus: HLA-antigen frequencies dependent on the age of onset of the disease

Journal of Immunogenetics
G SchernthanerW R Mayr

Abstract

A close correlation between juvenile mellitus and HLA-B8, HLA-BW15 and HLA-CW3 was found. Association of these antigens with juvenile diabetes mellitus was closely dependent on the ages of onset of the disease. Frequencies of BW15 and CW3 showed a remarkably low incidence in the childhood diabetics (0-15 years old) and were found increased in the patients with later (16 years or older) onset diabetes. HLA-B8 frequencies were found increased in all the groups of diabetics with different ages of onset. These findings point to the importance of HLA-B8 in childhood and HLA-B8, BW15 and CW3 in the later onset juvenile onset diabetes mellitus (JOD).

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Citations

Jan 1, 1977·Archives of Virology·A L Notkins
Feb 1, 1995·Human Immunology·B D TaitM C Honeyman
Jul 1, 1977·Clinical Immunology and Immunopathology·R M Galbraith, H H Fudenberg
Jul 1, 1979·Acta diabetologica latina·E Pimentel

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