PMID: 9165474May 1, 1997Paper

Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature

Journal of Pediatric Surgery
E BouffetM David

Abstract

The clinical and pathological features of three cases of juvenile granulosa cell tumors occurring in infants were studied. Precocious pseudopuberty developed in two patients and acute abdominal symptoms related to the rupture of the tumor developed in one. Surgery was the only treatment in each case and no adjuvant therapy was delivered. No patient experienced relapse. Histological examination showed a predominantly diffuse pattern with prominent luteinization. Call-Exner bodies were absent. Two tumors had multilocular thin walled cysts containing large amounts of estradiol, the third one contained rudimentary microfollicles. The prognosis of juvenile granulosa cell tumors in infancy appears more favorable than those occurring in older patients. No case of tumor recurrence has been reported in infancy so far. Surgery appears to be the state-of-the-art treatment of these tumors and additional therapy (chemotherapy or radiotherapy) must be discussed with caution, even in advanced stages.

References

Oct 1, 1978·Journal of Pediatric Surgery·J I HollenbeckW H Donnelly
Dec 1, 1991·Journal of Pediatric Surgery·D P CroitoruF M Guttman
Feb 1, 1968·Cancer·H J Norris, H B Taylor
Jan 1, 1962·The Journal of Pediatrics·R L REIS, C E KOOP

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Citations

Apr 7, 2009·Journal of Pediatric Hematology/oncology·Moisés Leyva-CarmonaFrancisco Lendinez-Molinos
Sep 8, 2006·Journal of Endocrinological Investigation·D LarizzaS Cesari
Jan 17, 2012·Journal of Pediatric Surgery·Mohamed Moncef HamdaneKhaled Ben Romdhane
Apr 6, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Ahmed IqbalJonathan Webster
Aug 16, 2011·The American Journal of the Medical Sciences·Hongmei XuJin He
Oct 6, 2016·Journal of Pediatric and Adolescent Gynecology·Hao WuRajkumar Venkatramani
Jun 21, 2005·International Journal of Clinical Practice·D Kulkarni, D J Pinto
Sep 22, 2012·British Journal of Haematology·P McKayUNKNOWN British Committee for Standards in Haematology
Feb 12, 2014·American Journal of Clinical Pathology·Nathan D Montgomery, Yuri Fedoriw
Oct 2, 2015·Veterinary Surgery : VS·Lucinda L van SteeTim J Scase
Jun 21, 2020·American Journal of Clinical Pathology·Yuhong YeShie Wang

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