Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study

Gynecologic Oncology
G CalaminusU Göbel

Abstract

Clinical and pathological data from 33 prospective registered patients who suffered from juvenile granulosa cell tumors (JGCT) were evaluated according to treatment and outcome. The median age at the time of diagnosis was 7.6 years (range, 6 months to 17.5 years). Fourteen patients showed signs of a pseudo-precocious puberty. In 1 patient premenarcheal bleeding was the only clinical symptom of the disease. A pelvic tumor or an abdominal distention was found in 6 children, revealing signs of an acute abdomen in 3 children. Tumor staging was performed according to the FIGO (International Federation of Gynecology and Obstetrics) classification for ovarian tumors. Twenty children and adolescents were classified as FIGO stage Ia; 8 children had stage Ic tumors. In 4 patients stage IIc and in 1 patient stage IIIc tumors were observed. For local tumor control all 33 patients underwent tumor resection and oophorectomy, which was complete in 28 patients. Adjuvant combination chemotherapy was used in 1 girl who presented with high mitotic pathological index features in FIGO stage Ia. In 8 other children between FIGO stage Ic and IIIc, treatment was also intensified by multidrug chemotherapy. After a follow-up period of 168 months, an eve...Continue Reading

References

Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S A SwansonJ E Wheeler

❮ Previous
Next ❯

Citations

May 31, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emanuela D'AngeloJaime Prat
Oct 3, 2006·Srpski arhiv za celokupno lekarstvo·Katarina MitrovićZoran Stanković
Jun 20, 2013·World Journal of Surgical Oncology·Sakina SekkateHassan Errihani
Nov 12, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicolas Kalfa, Charles Sultan
Aug 3, 2011·Radiologic Clinics of North America·Ricki U ShahLisa H Lowe
Jul 14, 2010·Journal of Pediatric Surgery·Sarah C OltmannAnne C Fischer
Jan 29, 2010·Journal of Pediatric Surgery·Sarah C OltmannAnne Fischer
Jun 16, 2009·Journal of Pediatric Surgery·Sarah C OltmannNilda Garcia
Jul 25, 2015·Pediatric Blood & Cancer·Brice FresneauCatherine Patte
Apr 14, 2011·Pediatric Blood & Cancer·Giovanni CecchettoGianni Bisogno
Mar 7, 2006·Gynecologic Oncology·Hongyan GuoJohn K Chan
Jul 16, 2002·Radiologic Clinics of North America·Fergus V Coakley
Aug 6, 2004·American Journal of Obstetrics and Gynecology·Stephen D FraustoAnil K Sood
Apr 6, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Ahmed IqbalJonathan Webster
Jan 3, 2009·Gynécologie, obstétrique & fertilité·N KalfaC Sultan
Oct 6, 2016·Journal of Pediatric and Adolescent Gynecology·Hao WuRajkumar Venkatramani
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James I Geller, Victor M Santana
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D T SchneiderR Wessalowksi
Apr 23, 2005·Seminars in Pediatric Surgery·Daniel von Allmen
Mar 31, 2000·Medical and Pediatric Oncology·J D Daubenton, C Sinclair-Smith
Oct 19, 2004·Pediatric Blood & Cancer·Kris Ann P SchultzMarie E Steiner
Sep 13, 2007·Archives of Gynecology and Obstetrics·Benjamin PiuraRuthy Shaco-Levy
Nov 22, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M HirakawaY Aoki
Dec 25, 2008·Current Opinion in Oncology·Stacey Jamieson, Peter J Fuller
Sep 8, 2006·Journal of Endocrinological Investigation·D LarizzaS Cesari
May 29, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Maria Korpal-SzczyrskaAnna Balcerska
Aug 8, 2014·Obstetrical & Gynecological Survey·Jessica E StineJohn T Soper
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicoletta ColomboAlessandra Insinga
Jan 11, 2007·Human Reproduction Update·Antonio La Marca, Annibale Volpe
Jun 21, 2020·American Journal of Clinical Pathology·Yuhong YeShie Wang
May 7, 2002·Journal of Pediatric Hematology/oncology·Anat Erdreich-EpsteinJudith G Villablanca
May 16, 2017·Current Oncology Reports·Lauren Pommert, William Bradley
Dec 14, 2011·Pediatric Surgery International·Amos Hong Pheng LohChan Hon Chui
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan Tinsley Schumer, Stephen A Cannistra
Feb 16, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Alice BergaminiGiorgia Mangili
Feb 24, 2021·Pediatric Hematology and Oncology·İdil Rana UserSaniye Ekinci
Mar 17, 2021·Annals of Diagnostic Pathology·Gupta ParikshaaSrinivasan Radhika

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Azamsadat MousaviHadi Shojaei
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Marjolijn B VerbruggenRené H M Verheijen
© 2021 Meta ULC. All rights reserved