PMID: 2493154Feb 1, 1989Paper

Juvenile hormone bisepoxide biosynthesis in vitro by the ring gland of Drosophila melanogaster: a putative juvenile hormone in the higher Diptera

Proceedings of the National Academy of Sciences of the United States of America
D S. RichardL I Gilbert

Abstract

The in vitro production of juvenile hormone (JH) was investigated by using isolated ring glands from third instar Drosophila melanogaster. A JH-like molecule is secreted that comigrates with a synthetic sample of methyl 6,7;10,11-bisepoxy-3,7,11-trimethyl-(2E)-dodecenoate (JHB3) during TLC, liquid chromatography, and GC analysis. Purified product from farnesoic acid-stimulated ring glands was analyzed by electron impact GC/MS and gave a mass spectrum identical to synthetic JHB3. Additional structure confirmation was obtained following conversion of product from unstimulated biosynthesis to a derivative that comigrated on liquid chromatography with the derivative prepared from synthetic JHB3. Physiological studies revealed that JHB3 is produced solely by the corpus allatum portion of the ring gland in vitro. Isolated ring glands from other cyclorrhaphous dipteran larvae also produce JHB3 almost exclusively in vitro. Corpora allata from mosquito larvae, however, produce only JH III, indicating that JHB3 production may be restricted to the higher Diptera. Topically applied synthetic JHB3 caused developmental responses in newly formed D. melanogaster white puparia similar to those obtained with JH III. The data suggest that JHB3 is...Continue Reading

References

Jan 1, 1987·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·V C HenrichL I Gilbert
Nov 1, 1986·Molecular and Cellular Endocrinology·M Gadot, S W Applebaum
Jan 1, 1986·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·B Roberts, L I Gilbert
Jan 1, 1966·Zeitschrift für Zellforschung und mikroskopische Anatomie·R C KingD Bodenstein
Jan 1, 1980·Annual Review of Physiology·L I GilbertN A Granger

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Citations

Jan 1, 1996·Archives of Insect Biochemistry and Physiology·P MoshitzkyS W Applebaum
Jan 1, 1993·Archives of Insect Biochemistry and Physiology·D Segal
Jan 1, 1995·Archives of Insect Biochemistry and Physiology·C Turner, T G Wilson
Jan 22, 1990·Molecular and Cellular Endocrinology·D S RichardL I Gilbert
Oct 1, 1991·Molecular and Cellular Endocrinology·M AltaratzD Segal
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Blazsek
May 1, 1994·Insect Biochemistry and Molecular Biology·D BorovskyE van Handel
Sep 1, 1995·Insect Biochemistry and Molecular Biology·V C Henrich, N E Brown
Nov 6, 2003·Insect Biochemistry and Molecular Biology·P MoshitzkyS W Applebaum
Nov 6, 2003·Insect Biochemistry and Molecular Biology·Yiping LiFernando G Noriega
Oct 15, 2013·General and Comparative Endocrinology·Davy JonesPeter E A Teal
May 29, 2003·Journal of Insect Physiology·L I. GilbertD S. Richard
Nov 24, 2001·Insect Biochemistry and Molecular Biology·G JonesD Jones
Sep 1, 1996·Insect Biochemistry and Molecular Biology·T M KhlebodarovaB D Hammock
Aug 27, 1998·Insect Biochemistry and Molecular Biology·P M CampbellM J Healy
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Henry ChungPhillip J Daborn
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L Shemshedini, T G Wilson
Jun 12, 2008·Genome Génome / Conseil National De Recherches Canada·Yong-Lei Zhang, Zheng-Xi Li
Feb 17, 1999·Annual Review of Entomology·R Feyereisen
Jul 20, 2013·BMC Biology·Rochele YamamotoMarc Tatar
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·G Jones, P A Sharp
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·T D SutherlandR Feyereisen
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·C HelvigR Feyereisen
Sep 30, 2004·Journal of Insect Science·Souphatta SasorithJean-Marie Wurtz
Jun 1, 1997·In Vitro Cellular & Developmental Biology. Animal·G L HolbrookC Schal
Jul 6, 2000·Insect Biochemistry and Molecular Biology·L I GilbertR M Roe
Mar 1, 2011·General and Comparative Endocrinology·William G BendenaStephen S Tobe
Jun 15, 2010·Journal of Insect Physiology·Grace JonesJean-Rene Martin
May 13, 2009·Molecular and Cellular Endocrinology·Jun WangWalter G Goodman

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