Juvenile idiopathic arthritis-associated uveitis

Best Practice & Research. Clinical Rheumatology
Ethan S Sen, Athimalaipet V Ramanan

Abstract

Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and thus carries a considerable risk of morbidity with associated reduction in quality of life. The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. Therefore, screening for JIA-associated uveitis in at-risk patients is essential. The aim of early detection and treatment is to minimise intraocular inflammation and to avoid complications that lead to visual loss, which can result from both disease activity and medications. The sight-threatening complications of JIA-associated uveitis include cataracts, glaucoma, band keratopathy, and macular oedema. There is increasing evidence for the early introduction of systemic immunosuppressive therapies to reduce topical and systemic use of glucocorticoids. A recently published randomised controlled trial of adalimumab in JIA-associated uveitis now provides convincing evidence for the use of this biologic in patients who fail to respond adequately to methotrexate. Tocilizumab and abatacept are be...Continue Reading

Citations

Mar 1, 2019·International Journal of Rheumatic Diseases·Su-Boon YongJames Cheng-Chung Wei
Mar 2, 2019·Ocular Immunology and Inflammation·Massimo AccorintiMarta Gilardi
Mar 8, 2019·Current Opinion in Ophthalmology·Julie GueudryBahram Bodaghi
Oct 30, 2019·Arthritis Research & Therapy·Elisabet BertholdRobin Kahn
Dec 5, 2019·Journal of Clinical Medicine·Raela B RidleyCristhian J Ildefonso
Sep 10, 2019·Rheumatology·Mustafa ÇakanDilbade Yıldız Ekinci
Jan 30, 2019·Case Reports in Rheumatology·Miyoko ImayoshiShuichi Yamamoto
Jan 1, 2019·Expert Review of Ophthalmology·Lucas KimJessica Shantha
Dec 13, 2019·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ethan S Sen, A V Ramanan
Mar 9, 2021·Therapeutic Advances in Ophthalmology·Judy L ChenEdmund Tsui
Sep 25, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Semanur OzdelMehmet Bulbul
Oct 23, 2020·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·H MalcováJ Heissigerová
Dec 30, 2021·International Ophthalmology Clinics·Cole A Martin, Eric L Crowell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Rheumatology Online Journal
Sarah L N ClarkeAthimalaipet V Ramanan
Nature Reviews. Rheumatology
Ethan S SenAthimalaipet V Ramanan
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Adriano MagliMaria Alessio
© 2022 Meta ULC. All rights reserved