Juvenile Idiopathic Arthritis: Diffusion-weighted MRI in the Assessment of Arthritis in the Knee

Radiology
Anouk M BarendregtRobert Hemke

Abstract

Background Diffusion-weighted imaging (DWI) can depict the inflamed synovial membrane in arthritis. Purpose To study the diagnostic accuracy of DWI for the detection of arthritis compared with the clinical reference standard and to compare DWI to contrast material-enhanced MRI for the detection of synovial inflammation. Materials and Methods In this institutional review board-approved prospective study, 45 participants with juvenile idiopathic arthritis (JIA) or suspected of having JIA (seven boys, 38 girls; median age, 14 years [interquartile range, 12-16 years]) were included between December 2015 and December 2018. Study participants underwent pre- and postcontrast 3.0-T MRI of the knee with an additional DWI sequence. For the clinical reference standard, a multidisciplinary team determined the presence or absence of arthritis on the basis of clinical, laboratory, and imaging findings (excluding DWI). Two data sets were scored by two radiologists blinded to all clinical data; data set 1 contained pre- and postcontrast sequences (contrast-enhanced MRI), and data set 2 contained precontrast and DWI sequences (DWI). Diagnostic accuracy was determined by comparing the scores of the DWI data set to those of the clinical reference...Continue Reading

References

Aug 13, 2015·Radiology·Daniel C SullivanUNKNOWN RSNA-QIBA Metrology Working Group
Apr 20, 2016·Pediatric Rheumatology Online Journal·Alessandro ConsolaroAngelo Ravelli
Mar 21, 2017·Arthritis Care & Research·Kiem OenUNKNOWN the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators
Oct 14, 2017·Pediatric Rheumatology Online Journal·Alexander SauerHenning Neubauer
May 17, 2018·Pediatric Radiology·Robert HemkeMario Maas
May 17, 2018·Pediatric Radiology·Clara MalattiaSilvia Magni-Manzoni
Nov 6, 2018·Pediatric Neurology·Ismail Elbeshlawi, Mohamed S AbdelBaki

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Citations

Jun 28, 2021·Zeitschrift für medizinische Physik·Thomas HüfkenVolker Rasche
Sep 23, 2021·NMR in Biomedicine·Halston J C SandfordValentina Mazzoli

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