Juvenile Idiopathic Inflammatory Myopathies

Pediatric Clinics of North America
Adam M Huber

Abstract

The juvenile idiopathic inflammatory myopathies (JIIM) are a group of rare, chronic, autoimmune illnesses that affect muscle and, to a lesser extent, skin. The presence of new-onset weakness and, in juvenile dermatomyositis, typical rahes, should lead to consideration of these diagnoses. Careful evaluation to exclude alternative diagnoses is needed. Investigations include a variety of blood tests, imaging, and possibly muscle biopsy. Validated clinical assessments are available for monitoring. Standard treatment includes corticosteroids and methotrexate and often extends beyond 1 year. Outcomes are generally good, but disease persistence remains problematic. Early involvement of providers with expertise in JIIM is essential.

Citations

Sep 19, 2019·Rheumatology International·Dimitri Poddighe, Kaisar Dauyey
Apr 20, 2019·Frontiers in Immunology·Ann Marie ReedJeffrey Arthur Dvergsten
Jan 24, 2019·International Journal of Molecular Sciences·Giovanna FerraraRolando Cimaz
Jan 17, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jessica L StahlRoberto Gordillo
Nov 25, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L Turnier, J Michelle Kahlenberg
Nov 26, 2020·Clinical Reviews in Allergy & Immunology·Chin-An Yang, Bor-Luen Chiang
Feb 9, 2021·Current Rheumatology Reports·Ovgu Kul CinarClarissa A Pilkington
Apr 28, 2021·Current Pediatric Reviews·Alexander K C LeungAlex H C Wong

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