PMID: 2506007Jan 1, 1989Paper

Juvenile myoclonic epilepsy: long-term response to therapy

Epilepsia
J K PenryA R Riela

Abstract

Data from 50 patients with juvenile myoclonic epilepsy (JME) were analyzed retrospectively to assess the response to drug therapy--long-term seizure control, relapse rates, and confounding factors in seizure recurrence. Valproate is the only available antiepileptic drug that has been shown to be effective in controlling the generalized seizure components of JME--myoclonic, tonic--clonic, and absence seizures--without significant side effects. Data were collected using the EpiMonitor software and represented case follow-up from 2 months to 9 years. Forty-three patients (86%) were seizure free for at least 1 year; 25 patients (50%) relapsed at some point during follow-up. Relapses were precipitated most frequently by fatigue, noncompliance, stress, sleep deprivation, and alcohol consumption. With accurate diagnosis and appropriate therapy, seizures in JME can be adequately controlled, although JME is a chronic disorder that may require lifelong therapy. To minimize relapse, patient management must also focus on patient lifestyle to eliminate or control lifestyle-associated precipitants of seizure relapse.

References

Jan 1, 1989·Epilepsia·R L Macdonald
May 1, 1988·Epilepsia·T Obeid, C P Panayiotopoulos
Jan 1, 1988·Genetic Epidemiology·D A GreenbergH Widelitz
Nov 1, 1985·Acta Neurologica Scandinavica·D Janz
Jun 23, 1983·The New England Journal of Medicine·A V Delgado-EscuetaG O Walsh
Feb 1, 1984·Epilepsia·J Asconapé, J K Penry
Mar 1, 1984·Neurology·A V Delgado-Escueta, F Enrile-Bacsal
Dec 1, 1982·Epilepsia·A CovanisP M Jeavons

❮ Previous
Next ❯

Citations

Mar 27, 2004·Current Treatment Options in Neurology·Joseph E. Sullivan, Dennis J. Dlugos
Jan 1, 1995·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K Iu MukhinM Iu Nikanorova
Dec 1, 1992·Seizure : the Journal of the British Epilepsy Association·M P CaneviniR Canger
Sep 12, 2003·Seizure : the Journal of the British Epilepsy Association·J VijaiK Radhakrishnan
Mar 1, 1993·Seizure : the Journal of the British Epilepsy Association·R M Dasheiff, A L Ritaccio
Apr 21, 1998·Seizure : the Journal of the British Epilepsy Association·J M MurthyA K Meena
Apr 21, 1998·Seizure : the Journal of the British Epilepsy Association·D AtakliB Arpaci
May 25, 2002·Epilepsia·Anthony G MarsonUNKNOWN Epilepsy Monotherapy Trial Group
Dec 4, 2003·Epilepsia·Ilo E Leppik
Feb 13, 2008·Epilepsia·Nicola SpecchioLuigi Maria Specchio
May 1, 1997·Acta Neurologica Scandinavica·S JainM C Maheshwari
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C Knott, C P Panayiotopoulos
Oct 8, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ioannis KarakisAndrew J Cole
Mar 1, 1994·Child: Care, Health and Development·N Gordon
May 13, 1998·Epilepsia·E PeruccaO Dulac
Mar 1, 1994·Epilepsia·M E LancmanJ K Penry
Mar 1, 1994·Epilepsia·C P PanayiotopoulosA R Tahan
Nov 9, 2011·Seminars in Pediatric Neurology·Shaun Hussain, Raman Sankar
Dec 21, 2007·Lancet Neurology·Miquel Raspall-ChaureRod C Scott
May 1, 2007·Epilepsy & Behavior : E&B·Belinda PlattnerMartha Feucht
Nov 14, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Domenico RestucciaGiacomo Della Marca
May 6, 2014·Seizure : the Journal of the British Epilepsy Association·Sita JayalakshmiSurath Mohandas
Nov 10, 2001·Seizure : the Journal of the British Epilepsy Association·S CallejaC H Lahoz
Sep 14, 2000·Seizure : the Journal of the British Epilepsy Association·M C Fernando-DongasA M Husain
Apr 12, 2002·Seizure : the Journal of the British Epilepsy Association·Hiroo MatsuokaMitsumoto Sato
Feb 22, 2001·Seizure : the Journal of the British Epilepsy Association·Z Martinović
Jun 19, 2007·Seizure : the Journal of the British Epilepsy Association·Dragoslav SokicAleksandra R Sindjelic
Apr 16, 2011·Seizure : the Journal of the British Epilepsy Association·Milen PavlovićTatjana Pekmezović
Jun 14, 2013·Epilepsy & Behavior : E&B·Dorothée G A Kasteleijn-Nolst TrenitéSándor Beniczky
Jun 14, 2013·Epilepsy & Behavior : E&B·Pierre GentonJavier Salas-Puig
Jun 14, 2013·Epilepsy & Behavior : E&B·Pierre Genton, Philippe Gelisse
Jun 14, 2013·Epilepsy & Behavior : E&B·Arielle CrespelPierre Genton
Apr 16, 2016·Expert Review of Neurotherapeutics·Martin J Brodie
Nov 1, 2005·Arquivos de neuro-psiquiatria·Patrícia da Silva SousaElza Márcia T Yacubian
Apr 1, 1990·Current Problems in Pediatrics·R R Clancy
Jul 1, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Aug 10, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittCatrin Tudur Smith
Oct 20, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Bruria Ben-ZeevTally Lerman-Sagie
Jun 17, 2006·Acta Neurologica Scandinavica. Supplementum·A AldenkampA Covanis
Feb 24, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C Baise-ZungR M Grossmann
Jun 21, 2006·Expert Review of Neurotherapeutics·Alberto VerrottiEmilio Franzoni
Jun 17, 2009·Expert Opinion on Pharmacotherapy·Danielle M AndradeBerge A Minassian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.