Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories.

Frontiers in Behavioral Neuroscience
Jesse D CushmanM S Fanselow

Abstract

Postnatal neurogenesis (PNN) contributes neurons to olfactory bulb (OB) and dentate gyrus (DG) throughout juvenile development, but the quantitative amount, temporal dynamics and functional roles of this contribution have not been defined. By using transgenic mouse models for cell lineage tracing and conditional cell ablation, we found that juvenile neurogenesis gradually increased the total number of granule neurons by approximately 40% in OB, and by 25% in DG, between 2 weeks and 2 months of age, and that total numbers remained stable thereafter. These findings indicate that the overwhelming majority of net postnatal neuronal addition in these regions occurs during the juvenile period and that adult neurogenesis contributes primarily to replacement of granule cells in both regions. Behavioral analysis in our conditional cell ablation mouse model showed that complete loss of PNN throughout both the juvenile and young adult period produced a specific set of sex-dependent cognitive changes. We observed normal hippocampus-independent delay fear conditioning, but excessive generalization of fear to a novel auditory stimulus, which is consistent with a role for PNN in psychopathology. Standard contextual fear conditioning was intac...Continue Reading

Citations

Nov 13, 2013·Neurobiology of Learning and Memory·Michael S FanselowSarah Hersman
Jan 19, 2016·Frontiers in Systems Neuroscience·Sarah HersmanMichael Fanselow
Apr 26, 2015·Behavioural Brain Research·Laurence CoutellierRyan Shepard
Sep 3, 2013·Stress : the International Journal on the Biology of Stress·C M McCormickJ J Simone
Jun 2, 2015·Journal of Neurodevelopmental Disorders·Tine VerreetMohammed Abderrafi Benotmane
Apr 18, 2018·Hippocampus·Rose-Marie KarlssonHeather A Cameron
Sep 8, 2018·The European Journal of Neuroscience·Thiago F A França
Jul 13, 2019·Aging Cell·Danka A KozarevaYvonne M Nolan
Jul 20, 2012·Critical Care Medicine·Sulpicio G Soriano
Sep 27, 2019·Scientific Reports·Ann N HoffmanMichael S Fanselow
Feb 8, 2019·Frontiers in Behavioral Neuroscience·Ching-San TsengYi-Shuian Huang
Nov 27, 2020·Progress in Neurobiology·Jesse D CushmanFranklin B Krasne
Jul 22, 2018·Neurobiology of Learning and Memory·Thiago F A França

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