Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options

Best Practice & Research. Clinical Rheumatology
Christian M HedrichMichael W Beresford

Abstract

The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE) manifests before the age of 16 years in 10-20% of all cases. Clinical courses are more severe, and organ complications are more common in patients with juvenile SLE. Varying gender distribution in different age groups and increasing severity with younger age and the presence of monogenic disease in early childhood indicate distinct differences in the pathophysiology of juvenile versus adult-onset SLE. Regardless of these differences, classification criteria and treatment options are identical. In this article, we discuss age-specific pathomechanisms of juvenile-onset SLE, which are currently available and as future treatment options, and propose reclassification of different forms of SLE along the inflammatory spectrum from autoinflammation to autoimmunity.

Citations

May 17, 2019·Advances in Rheumatology·Adriana Rodrigues FonsecaSheila Knupp Feitosa de Oliveira
Oct 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sigrun R HofmannChristian M Hedrich
Jul 25, 2019·Frontiers in Immunology·Anna Elisa Andrea Surace, Christian M Hedrich
Sep 19, 2020·Zeitschrift für Rheumatologie·E Kayacan ErdoganD Arslan
Dec 15, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Liza J McCann, Christian M Hedrich
Feb 12, 2021·Current Rheumatology Reports·A CharrasC M Hedrich
Jul 2, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Emil CarlssonChristian M Hedrich
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva
Oct 7, 2021·Topics in Magnetic Resonance Imaging : TMRI·Matias NegrottoTodd A Abruzzo
Nov 9, 2021·Zeitschrift für Rheumatologie·Tobias Alexander, Christian M Hedrich

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