PMID: 6974234Oct 1, 1981Paper

Juvenile rheumatoid arthritis in children with diabetes mellitus

The Journal of Pediatrics
M C RudolfJ M Dwyer

Abstract

Seven children with insulin-dependent diabetes mellitus were found to have juvenile rheumatoid arthritis; six of these children had the polyarticular form of the disease. All six had positive serology (rheumatoid factor and/or antinuclear antibody) and clinical or serologic evidence of autoimmune diseases usually ascribed to the thyrogastric cluster. Five expressed HLA antigens associated with increased risk for both diabetes and rheumatoid arthritis in adults. Evidence of B cell hyperactivity and impaired T cell response was found in some, but immunoregulatory function was normal in all. The association of these two diseases may be the result of factors other than chance alone, and may be more common than previously suspected.

References

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Citations

Nov 11, 1999·Arthritis and Rheumatism·D N Glass, E H Giannini
Jul 23, 2008·Pediatric Rheumatology Online Journal·Sampath Prahalad, David N Glass
May 1, 1997·Rheumatic Diseases Clinics of North America·J A Fitch, B H Singsen
Dec 17, 2011·The Journal of Rheumatology·Heini PohjankoskiAnneli Savolainen
Apr 4, 2006·Arthritis and Rheumatism·Peter A Nigrovic, Patience H White
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Eric C Gowing, Kevin M McKown
Dec 14, 2004·Arthritis and Rheumatism·Sampath PrahaladJohn Bohnsack

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