Juvenile Xanthogranuloma: Case Report and Literature Review

International Medical Case Reports Journal
Sadegh Vahabi-AmlashiZahra Tafazzoli

Abstract

Juvenile Xanthogranuloma (JXG) is a relatively uncommon non-Langerhans cell histiocytosis, which often occurs at an early age and is usually asymptomatic. Herein, we present the case of a 17-year-old man with numerous asymptomatic yellow-brown papulonodular lesions with a symmetric distribution on upper and lower extremities, face, and trunk, developed over the past 4 years. In the histopathologic examination, histiocytes with a Touton-like appearance were observed in favor of xanthogranuloma. The patient was treated with isotretinoin 20 mg daily for 2 months, which surprisingly led to the progression of lesions and thus was discontinued. Although JXG may cause severe morbidities in some circumstances, it is a self-limiting benign disorder and patients should be assured regarding the benign self-regressive nature of the disease.

References

Nov 1, 1993·Journal of the American Academy of Dermatology·R CaputoF Cottoni
May 9, 2003·Acta Dermato-venereologica·Sung-Jan Lin, Hsien-Ching Chiu
Dec 2, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Nathalie SaadLuc Thomas
Mar 18, 2009·Archives of Dermatology·Angela J WoodLawrence E Gibson
Jul 1, 2011·Indian Journal of Dermatology·Arun AcharMallika Pal
Oct 25, 2013·Singapore Medical Journal·Lixian Chris TanChen Wee Derrick Aw
Jul 6, 2015·Dermatologic Clinics·Sarah S ChisolmLindy P Fox
May 26, 2017·Anais Brasileiros De Dermatologia·Bárbara Roque FerreiraÓscar Tellechea
Feb 23, 2018·American Journal of Ophthalmology Case Reports·Peter MeyerElisabeth Bruder
Oct 16, 2018·Ocular Oncology and Pathology·Hidetsugu MoriKanji Takahashi

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Citations

Sep 5, 2020·Curēus·Katelyn UrbanRick Bains
Oct 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Leonardo Peruilh-BagoliniAimilios Lallas

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Methods Mentioned

BETA
X-ray
biopsy

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