Juxtaglomerular cell activity during hemorrhage and ischemia as revealed by quinacrine histofluorescence

Acta Physiologica Scandinavica
M Alund

Abstract

Quinacrine (QC) binds with high affinity to the intracellular storage granules of juxtaglomerular cells (JG-cells) in the afferent arteriolus of the glomerulus of the kidney. The present study tests whether QC bound to JG-cells can be released. The cells were stimulated by renal ischemia and hemorrhagic shock combined with immobilization stress. 1 h after onset of renal ischemia QC-JGI (modified Hartroft & Hartroft 1953) in 14C-QC-treated rats had decreased to about 40% in the ischemic kidney compared to a not ligated control kidney. The 14C-contents in the ischemic kidney had decreased to 33% of that in the untouched control kidney. Hemorrhagic shock was obtained by bleeding into a reservoir for 15 min or 1 h. Rats who received QC or 14C-QC 1 h before onset of bleeding showed no change in QC-JGI (15 min shock) or 14C-contents (1 h shock) as compared to controls. This was probably due to formation of new QC-binding granules, which took up still circulating quinacrine thereby masking a release. If the time between the QC injection and the onset of shock was extended to about 15 h, when circulating amounts of QC are very low, a decrease of QC-JGI (about 30% of controls) was seen in the kidneys of the shocked rats. The results are...Continue Reading

References

May 1, 1978·British Journal of Pharmacology·G BurnstockL Kasakov
Jan 1, 1978·Annual Review of Physiology·I A ReidW F Ganong
Sep 1, 1978·British Journal of Pharmacology·G BurnstockR Crowe
Jan 1, 1976·Physiological Reviews·J O Davis, R H Freeman
Sep 1, 1973·Antimicrobial Agents and Chemotherapy·C C Smith, C S Genther
Sep 1, 1969·The Journal of Clinical Endocrinology and Metabolism·N WinerA D Freedman
Jun 1, 1971·The American Journal of Physiology·E H BlaineR L Prewitt
Jan 1, 1970·Histochemie. Histochemistry. Histochimie·L Olson, U Ungerstedt
Jun 4, 1971·Brain Research·H CorrodiL Olson
Sep 1, 1965·The American Journal of Physiology·A J Vander
Nov 1, 1966·Journal of Applied Physiology·H Whigham, M H Weil
Mar 1, 1953·The Journal of Experimental Medicine·P M HARTROFT, W S HARTROFT

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Citations

Oct 1, 1980·Journal of the Autonomic Nervous System·M Alund, L Olson
Apr 17, 2008·Hypertension·Jung J KangJános Peti-Peterdi
Jun 3, 2010·Frontiers in Bioscience (Elite Edition)·Agnes Prokai, Janos Peti-Peterdi
Jun 23, 2011·Heart Failure Reviews·Nicolas F SchrotenRudolf A de Boer
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Oct 16, 2010·International Journal of Hypertension·Daniel Casellas
Jan 11, 2017·American Journal of Physiology. Renal Physiology·Charlotte BuckleyJohn J Mullins
Jul 27, 2006·American Journal of Physiology. Renal Physiology·László RosivallJános Peti-Peterdi
Apr 15, 2004·American Journal of Physiology. Renal Physiology·János Peti-PeterdiRobert H Chow
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Oct 12, 2007·Physiology·Frank SchwedaArmin Kurtz

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