Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord

Molecular and Cellular Neurosciences
P CarrollS Alonso

Abstract

The CNR (cadherin-related neuronal receptors) family of protocadherins is of great interest because of their potential roles as molecular tags in the formation of specific synaptic connections, and as receptors for reelin, during neuronal migration, and cell body positioning. In order to know more about potential functions of CNRs we have mapped their expression during mouse nervous system development and compared their expression with that of reelin and its intracellular effector Dab1 in several tissues. In spinal cord, CNRs and Dab1 are expressed in motoneurons, while reelin is located in adjacent cells. In the hindbrain, there is a differential expression of CNRs and Dab1 in various motor nuclei. In the retina and olfactory system, we observe CNR and reelin expression but not that of Dab1. These results provide new insights into the potential functions of CNRs and their possible integration in the reelin pathway during development.

References

Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Mar 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R WettsJ E Vaughn
Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Apr 1, 1993·The Journal of Comparative Neurology·P E PhelpsJ E Vaughn
May 1, 1997·The European Journal of Neuroscience·S N SchiffmannA M Goffinet
Oct 23, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Ikeda, T Terashima
Apr 15, 1999·Annual Review of Neuroscience·M E Hatten
Nov 26, 1999·Neuron·G D'ArcangeloT Curran
Mar 8, 2000·Current Biology : CB·E C Gilmore, K Herrup
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J W YipC Capriotti
Jul 25, 2000·The Journal of Comparative Neurology·D S Rice, T Curran

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Citations

Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stefanie S SchalmTom Maniatis
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Nikolaos GiagtzoglouHugo J Bellen
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Scott RibichTom Maniatis
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Damien DerouetSylvie Chevalier
Feb 3, 2009·Experimental Neurology·Martin C MüllerCarola A Haas
Mar 26, 2016·Frontiers in Cellular Neuroscience·Ankita R Vaswani, Sandra Blaess
Dec 8, 2004·The European Journal of Neuroscience·Hirofumi MorishitaTakeshi Yagi
May 5, 2005·The European Journal of Neuroscience·Samia CohenFanny Mann
Oct 7, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Jean-Christophe MaurinFrançoise Bleicher
Jul 28, 2004·Molecular and Cellular Neurosciences·Martina BlankDarwin K Berg
Aug 16, 2005·Current Opinion in Cell Biology·Dirk JunghansRolf Kemler
Apr 12, 2005·Biological Psychiatry·S Hossein FatemiDavid A Pearce
Oct 3, 2003·Biology of Reproduction·Kamin J JohnsonEun J Kwon
Dec 1, 2004·Neuroreport·Hirofumi MorishitaTakeshi Yagi
Dec 4, 2003·The Journal of Comparative Neurology·Marc D KubasakPatricia E Phelps
Jan 30, 2004·The Journal of Comparative Neurology·Yee Ping YipJoseph W Yip
Jul 19, 2002·The Journal of Comparative Neurology·Arianna CostagliMarina Mione
May 16, 2003·Journal of Neuroscience Research·Sacha KallenbachKeith Dudley
Jul 21, 2006·Cell and Tissue Research·Kerstin PiechottaMarkus Missler
Sep 17, 2002·Current Opinion in Cell Biology·Marcus Frank, Rolf Kemler
Feb 21, 2003·Current Opinion in Neurobiology·Hsiao-Huei ChenEric Frank

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