Juxtaposition of somatostatin cell and parietal cell in the dog stomach

Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku
Y KusumotoT Fujita

Abstract

Immunohistochemical and silver impregnation techniques were applied to demonstrate the somatostatin producing D cells in the dog gastric body (oxyntic area). It was revealed that the D cells were frequently in direct contact with parietal cells, either by their cell body invaginated into or crescently attached to a parietal cell or by extending a cytoplasmic process ending in a synaptic button-like swelling. Some D cells and their processes appeared to contact chief cells. This morphological finding is correlated to the hypothesis that the D cells might receive an unknown stimulus, possible a mechanical extension of the gastric wall, and by its secretion, somatostatin, inhibit the release of gastric acid and enzymes. The direct juxtaposition and synapse-like connection of D and parietal cells seem to symbolize the continuity of neurons and endocrine cells (paraneurons) as well as neurotransmitters and hormones.

References

Mar 1, 1989·Digestive Diseases and Sciences·M R Lucey, T Yamada
Feb 1, 1991·American Journal of Respiratory Cell and Molecular Biology·T Shimosegawa, S I Said
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P NorlénR Håkanson
Jan 1, 1981·Vox Sanguinis·H Holmsen

Related Concepts

Enzymes, antithrombotic
Protoplasm
Neurons
Body of Stomach
Structure of Pyloric Gland
Somatostatin-Secreting Cells
Cell Communication
cell body
Process of Secretion
Cytoplasmic

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.