Juxtaposition of somatostatin cell and parietal cell in the dog stomach

Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku
Y KusumotoT Fujita


Immunohistochemical and silver impregnation techniques were applied to demonstrate the somatostatin producing D cells in the dog gastric body (oxyntic area). It was revealed that the D cells were frequently in direct contact with parietal cells, either by their cell body invaginated into or crescently attached to a parietal cell or by extending a cytoplasmic process ending in a synaptic button-like swelling. Some D cells and their processes appeared to contact chief cells. This morphological finding is correlated to the hypothesis that the D cells might receive an unknown stimulus, possible a mechanical extension of the gastric wall, and by its secretion, somatostatin, inhibit the release of gastric acid and enzymes. The direct juxtaposition and synapse-like connection of D and parietal cells seem to symbolize the continuity of neurons and endocrine cells (paraneurons) as well as neurotransmitters and hormones.


Mar 1, 1989·Digestive Diseases and Sciences·M R Lucey, T Yamada
Feb 1, 1991·American Journal of Respiratory Cell and Molecular Biology·T Shimosegawa, S I Said
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P NorlénR Håkanson
Jan 1, 1981·Vox Sanguinis·H Holmsen

Related Concepts

Enzymes, antithrombotic
Body of Stomach
Structure of Pyloric Gland
Somatostatin-Secreting Cells
Cell Communication
cell body
Process of Secretion

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