PMID: 3759657Aug 1, 1986Paper

K-252a, a potent inhibitor of protein kinase C from microbial origin

The Journal of Antibiotics
H KaseY Matsuda

Abstract

K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.

Citations

Dec 1, 1990·Journal of Industrial Microbiology·K S LamC J Pearce
Feb 1, 1991·Journal of Cellular Physiology·E M RosenI D Goldberg
Jan 1, 1989·Annals of the New York Academy of Sciences·K AbeK Kogure
Mar 1, 1995·Journal of Neuroscience Research·B NikodijevicG Guroff
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·A M CamorattoC A Dionne
Jul 9, 2003·Journal of Pediatric Hematology/oncology·Anne-Marie LangevinUNKNOWN Pediatric Oncology Group Study
Apr 1, 2005·PLoS Biology·Masahiro TanakaCynthia L Adams
Jan 10, 2009·The Journal of Antibiotics·Hirofumi Nakano, Satoshi Omura
Mar 19, 2014·Journal of Basic Microbiology·Rungroch Sungthong, Nareeluk Nakaew
Oct 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Thomas Leitz, Gabriele Klingmann
Jun 1, 2016·Israel Journal of Chemistry·Nicholas R O'ConnorBrian M Stoltz
Jan 1, 1992·Drug Metabolism Reviews·S Garattini
Sep 1, 1992·Agents and Actions·M J MulqueenA D Sedgwick
Oct 1, 1993·European Journal of Biochemistry·A Huwiler, J Pfeilschifter
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MorenoR Llinás
Jan 4, 2003·Chembiochem : a European Journal of Chemical Biology·Chang-Gu HyunJon S Thorson
Mar 12, 2017·Current Oncology Reports·Carlos Best-AguileraR Monserrat Rojas-Sotelo
Mar 24, 2018·Journal of Bioinformatics and Computational Biology·Suman Jyoti DekaVishal Trivedi
Oct 1, 1987·Medicinal Research Reviews·G L Kenyon, G A Garcia
Sep 1, 1989·Journal of Neuroscience Research·D M RauschG Guroff
Jul 1, 1990·Journal of Neuroscience Research·B NikodijevicG Guroff
Nov 1, 1995·Journal of Cellular Biochemistry·N ShinokiM Monden
Mar 2, 2006·The Journal of Antibiotics·Yufei FengMakoto Ubukata
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·A C WagnerB Göke
Sep 28, 2005·Organic & Biomolecular Chemistry·David MoffatNigel S Simpkins

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