PMID: 2494608Jan 2, 1989Paper

K-252a specifically inhibits the survival and morphological differentiation of NGF-dependent neurons in primary cultures of human dorsal root ganglia

Neuroscience Letters
P Doherty, F S Walsh

Abstract

We have measured neurofilament protein expression in cultures of human dorsal root ganglia (DRG) grown in both the presence and absence of nerve growth factor (NGF). Cultures established from DRG of 8-13 weeks gestation contained populations of both NGF-dependent and -independent neurofilament-positive cells. A recently described kinase inhibitor named K-252a inhibited NGF-dependent increases in neurofilament protein expression with half-maximal and maximal inhibition apparent at concentrations of 6 and 25 nM. At up to 50 nM, K-252a had no effect on neurofilament protein expression from NGF-independent neurons.

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Citations

Nov 1, 1992·The Histochemical Journal·E MaraniJ A Maassen
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·R M Zinkernagel, A Althage
Sep 30, 2005·American Journal of Physiology. Cell Physiology·Heather A DrummondDavid E Stec
Dec 1, 1992·Journal of Neurochemistry·B Knüsel, F Hefti

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