K+ channels which contribute to the acetylcholine-induced hyperpolarization in smooth muscle of the guinea-pig submucosal arteriole

The Journal of Physiology
H Hashitani, H Suzuki

Abstract

1. Membrane potentials were recorded from submucosal arterioles (diameter, 30-80 microns) of the guinea-pig small intestine, using conventional microelectrode techniques. In control solution the resting membrane potential was about -73 mV, and the addition of 0.5 mM Ba2+ depolarized the membrane to about -43 mV. 2. ACh (10 nM to 10 microM), or substance P (0.1 microM), caused a membrane hyperpolarization in preparations which had been depolarized by Ba2+ but not in control preparations. ACh produced a sustained hyperpolarization, whereas substance P produced a transient hyperpolarization, without being affected by either nitroarginine (0.1 mM) or indomethacin (10 microM). 3. In the presence of 50 microM BAPTA (acetoxymethyl ester form), the membrane potentials were not altered in the control solution or in the presence of Ba2+, but Ba2+ caused a smooth depolarization of the membrane. Following this procedure, both ACh and substance P caused membrane depolarization instead of hyperpolarization, suggesting that the ACh- and substance P-induced hyperpolarization in arteriolar smooth muscle are intracellular [Ca2+] dependent. 4. In short segments (200-500 microns) of arteriole, the time constant of electrotonic potentials produced ...Continue Reading

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Citations

May 26, 1998·European Journal of Pharmacology·K ShimamuraM Tanaka
Mar 17, 1999·British Journal of Pharmacology·A K HammarströmH A Coleman
Dec 22, 1999·British Journal of Pharmacology·T MuraiM Watanabe
Nov 18, 2000·British Journal of Pharmacology·K ImaedaH Suzuki
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May 4, 1999·Clinical and Experimental Pharmacology & Physiology·K ShimamuraS Sunano
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Mar 6, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hikaru Suzuki
Jul 1, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshimichi Yamamoto, Hikaru Suzuki
Jun 17, 1998·The Journal of Physiology·H HashitaniH Suzuki
May 21, 2005·The Journal of Physiology·Rebecca E Haddock, Caryl E Hill
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