PMID: 2107544Mar 1, 1990Paper

K(+)-evoked Müller cell depolarization generates b-wave of electroretinogram in toad retina

Proceedings of the National Academy of Sciences of the United States of America
R Wen, B Oakley

Abstract

We tested the hypothesis that a light-evoked increase in [K+]o produces a depolarization of the Müller cell membrane, which in turn generates the electroretinogram b-wave current. Using Bufo marinus isolated retinas and K(+)-selective microelectrodes, we recorded two distinct light-evoked increases in extracellular K+ concentration: one in the inner plexiform layer and the other near the outer plexiform layer; the "distal" K+ increase was found over only 10-microns depth and had a maximum amplitude of 0.3 mM. We also recorded the electroretinogram and the light-evoked responses of rods and Müller cells. After correction for the response time of the K(+)-selective microelectrode, the waveforms of all three of these responses were almost exactly as predicted by an earlier computer simulation of the K+/Müller cell hypothesis of the b-wave by Newman and Odette [Newman, E.A. & Odette, L.L. (1984) J. Neurophysiol. 51, 164-182]. The distal K+ increase and the b-wave varied in a similar manner as a function of stimulus irradiance. Superfusion with 0.2 mM Ba2+ attenuated both the Müller cell depolarization and the b-wave by approximately 65% but had no significant effect upon the distal K+ increase. Because Ba2+ reduces K+ conductance o...Continue Reading

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Citations

Jul 1, 1993·Journal of Chemical Neuroanatomy·A ReichenbachL Hertz
Apr 5, 2001·Progress in Retinal and Eye Research·G Niemeyer
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Fushun WangMaiken Nedergaard
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P J DeMarcoM K Powers
Jul 14, 2001·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·D A JacobsL J Balcer
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jakob S SatzKevin P Campbell
Aug 4, 2015·Journal of Natural Medicines·Fazli WahidYou Young Kim
Apr 14, 2016·Neural Plasticity·Joseph BouskilaMaurice Ptito
Aug 4, 2016·Visual Neuroscience·Joseph BouskilaMaurice Ptito
Jul 27, 2011·Journal of Ethnopharmacology·Fazli WahidYou Young Kim
Nov 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne-Marie GagnéMarc Hébert
Jun 1, 1997·Vision Research·A K EcksteinE Zrenner
Jul 14, 2005·Journal of Neurochemistry·Carolina O JaliffaRuth E Rosenstein
May 1, 2013·The Journal of Comparative Neurology·Joseph BouskilaJean-François Bouchard
Feb 13, 2020·Investigative Ophthalmology & Visual Science·Mirella Telles Salgueiro BarboniJan Kremers
Jul 24, 2021·Visual Neuroscience·Andrey V DmitrievRobert A Linsenmeier

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