PMID: 6103516Jan 1, 1980Paper

K+-evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine

Naunyn-Schmiedeberg's Archives of Pharmacology
H Osborne, A Herz

Abstract

The effects of drugs on the K+-evoked release of met-enkephalin from superfused rat striatal slices were investigated using a specific radioimmunoassay. GABA, at concentrations of 50 microM and 100 microM, and the GABA agonist muscimol (50 microM), significantly inhibited the release. The inhibitory effect of GABA was reversed by picrotoxin suggesting that GABA inhibition is mediated by GABA receptors. Selected concentrations of the dopamine agonists apomorphine and ergonovine, as well as of haloperidol, acetylcholine, carbachol, noradrenaline, glutamic acid and substance P, had no effect on the release of metenkephalin. Increases in the evoked release (80%) and striatal enkephalin content (60%) were found in rats after chronic haloperidol administration, pointing to an increase in the synthesis and utilization of striatal enkephalin. No differences were found between the release from slices from morphine-tolerant/dependent and naive rats or after addition of naloxone to slices derived from tolerant/dependent animals. Selected concentrations of morphine and naloxone had no effect on release suggesting the absence of a mechanism for the regulation of enkephalin release involving autoreceptors.

References

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Citations

Feb 20, 1984·Brain Research·G PasinettiM Trabucchi
May 13, 1985·Brain Research·S R George, M Kertesz
Mar 12, 1981·European Journal of Pharmacology·J Sawynok, F S Labella
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J E MorleyM T Lowy
Apr 1, 1991·Brain Research. Molecular Brain Research·S Reimer, V Höllt
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·K H Jhamandas
Jan 1, 1982·Progress in Neurobiology·R C Frederickson, L E Geary
Jan 1, 1983·General Pharmacology·A GrognetF V DeFeudis
Jan 1, 1981·Neuroscience·F CesselinM Hamon
Apr 1, 1987·Brain Research Bulletin·R S Root-Bernstein
Jun 1, 1991·Journal of Neurochemistry·N T MaidmentC J Evans
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·A Herz
Jun 1, 1989·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·W G ParrisD M Desiderio
Jun 15, 1983·Biochemical and Biophysical Research Communications·S L SabolJ S Hong
Mar 1, 1984·Journal of Autonomic Pharmacology·L G HársingE S Vizi

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