K+-permeability of the blood-brain barrier, investigated by aid of a K+-sensitive microelectrode

Acta Physiologica Scandinavica
A J HansenC Crone

Abstract

The K+-permeability of the blood-brain barrier at the capillary level was estimated from determinations of brain extracellular K+-concentration in response to an isotonic bolus containing KCl injected into the carotid artery. A very low permeability appeared from the fact that the extracellular K+-concentration--measured by aid of K+-sensitive microelectrodes--remained unchanged during the passage of the bolus. An upper limit for the blood-brain barrier K+-permeability in the rat was estimated to be 2.8 X 10(-7) cm. with s-1.

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Related Concepts

Blood - Brain Barrier Anatomy
Brain Chemistry
Extracellular Space
Intra-Arterial Injections
Mesentery
Microelectrodes
Muscle
Potassium
Slow-K

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