The K+-permeability of the blood-brain barrier at the capillary level was estimated from determinations of brain extracellular K+-concentration in response to an isotonic bolus containing KCl injected into the carotid artery. A very low permeability appeared from the fact that the extracellular K+-concentration--measured by aid of K+-sensitive microelectrodes--remained unchanged during the passage of the bolus. An upper limit for the blood-brain barrier K+-permeability in the rat was estimated to be 2.8 X 10(-7) cm. with s-1.
Rapid changes of potassium concentration at the outer surface of exposed single neurons during membrane current flow
Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats
The Zweifach International Award 1979. Ariadne's thread--an autobiographical essay on capillary permeability
Age-dependent decrease of the passive Rb+ and K+ permeability of the nerve cell membranes in rat brain cortex as revealed by in vivo measurement of the Rb+ discrimination ratio
Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level
Calcium-dependent regulation of potassium permeability in the glial perineurium (blood-brain barrier) of the crayfish
An in situ cytochemical evaluation of blood-brain barrier sodium, potassium-activated adenosine triphosphatase polarity
Angiotensin II, vasopressin and GTP[gamma-S] inhibit inward-rectifying K+ channels in porcine cerebral capillary endothelial cells
Effects of reduced cerebral blood flow upon EEG pattern, cerebral extracellular potassium, and energy metabolism in the rat cortex during bicuculline-induced seizures
Maintenance of eupnea and gasping following alterations in potassium ion concentration of perfusates of in situ rat preparation
Changes in extracellular potassium and calcium concentration and neural activity during prolonged electrical stimulation of the cat cerebral cortex at defined charge densities
Polarity of the blood-brain barrier: distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells
Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range
Quantitative measurement of blood-brain barrier permeability using rubidium-82 and positron emission tomography
Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca2+] and [H+] in the hippocampus during recovery from short-term, transient ischemia
Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats
Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow
Blood Brain Barrier Chips
The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.
Blood Brain Barrier
The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.