K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis

Journal of Cutaneous Pathology
Jag BhawanIL-11 Psoriasis Study Group

Abstract

K16, a type I keratin, is upregulated in hyperproliferative states including psoriasis. It has been used as a marker of psoriasis and its expression is upregulated in relapsing psoriasis and downregulating in resolving. We evaluated non-lesional psoriatic skin for K16 expression. Sixty-seven non-lesional and lesional skin samples from patients with psoriasis and normal skin from 19 non-psoriatic patients were studied by immunohistochemistry on frozen sections with K16. Seventeen of 19 normal skin samples showed staining of basal cells in the deeper part of the rete ridges. Sixty-two non-lesional psoriatic skin samples showed intense basal staining of K16. Of the remaining five non-lesional samples, diffuse intense suprabasal staining in one, pan-epidermal staining in two, and no staining was seen in two samples. Suprabasal (37), diffuse (14), sandwich (12), and basal (3) pattern staining were seen in psoriatic skin. One psoriatic skin sample did not show any expression. Our results demonstrate that K16 expression is also observed in non-lesional psoriatic skin and may serve as a marker of preclinical psoriasis.

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Citations

Nov 30, 2005·The American Journal of Dermatopathology·Jag BhawanMina Yaar
Jun 16, 2005·The Journal of Investigative Dermatology·Eunkyung ChungRobert J Coffey
Sep 2, 2011·The Journal of Investigative Dermatology·Yijun CarrierQuintus G Medley
Jun 3, 2006·The Journal of Investigative Dermatology·Nicholas R BensonGerald G Krueger
Nov 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dale TelgenhoffBraham Shroot
May 26, 2010·Experimental Dermatology·Andrea TrostKamil Onder
Mar 28, 2013·International Journal of Molecular Sciences·Kai H HänelJens Malte Baron
Jan 19, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jie MaXuejun Zhang
Apr 4, 2019·The Kaohsiung Journal of Medical Sciences·Jin-Guang ChenTian-Guo Cai
Apr 13, 2019·Journal of Proteomics·Noreen KarimRobert H Rice

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