Kadsurenone is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway

Oncology Letters
Tianhui HouJianru Xiao

Abstract

Breast cancer (BC) is characterized by high incidences of bone metastases. Current treatment strategies for BC bone metastases primarily focused on breaking the 'vicious osteolytic cycle'. Platelet-activating factor (PAF) is a potent phospholipid mediator, which has previously reported biological activities in BC progression and osteoclast differentiation by activating its receptor PAF receptor (PTAFR). However, the role of PAF in the mediation of BC bone metastases remains elusive. In the present study, it was revealed that the upregulation of PTAFR was associated with an increased incidence of bone metastases. It was also revealed that PAF significantly enhanced the processes of BC cell migration and BC mediated osteoclastogenesis. These results suggest that PAF serves a promotion role in BC bone metastases. It was further demonstrated that the natural PAF antagonist Kadsurenone may effectively attenuate each process by partially blocking the PAF/PTAFR signaling pathway. Therefore, targeting PAF/PTAFR by Kadsurenone may be a promising treatment strategy for BC bone metastases.

References

Oct 13, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·C W Imrie, C J McKay
Jul 5, 2003·Cancer Cell·Yibin KangJoan Massagué
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Jul 3, 2004·The Journal of Clinical Investigation·Hisako HikijiTakao Shimizu
Jan 18, 2005·The Journal of Surgical Research·James T Wu, John G Kral
Jun 28, 2005·Critical Reviews in Oncology/hematology·Giovanni Selvaggi, Giorgio V Scagliotti
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Aug 22, 2007·Mediators of Inflammation·Alexandros Basilios TsouprasConstantinos Alexandros Demopoulos
Dec 17, 2008·Recent Patents on Inflammation & Allergy Drug Discovery·Alicja Kasperska-ZajacBarbara Rogala
Dec 30, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shu-Pei HuangTung-Hu Tsai
Mar 25, 2009·Nature Reviews. Cancer·Don X NguyenJoan Massagué
May 20, 2011·Nature Reviews. Cancer·Katherine N WeilbaecherLaurie K McCauley
Nov 20, 2012·Fitoterapia·Preeti SinghVipin Kumar Garg
Mar 8, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Roger von MoosCarsten Bokemeyer
Mar 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David L Waning, Theresa A Guise
Sep 4, 2015·Breast Cancer Research : BCR·Daniele SantiniGiuseppe Tonini
Oct 22, 2015·International Journal of Immunopathology and Pharmacology·Krzysztof Pałgan, Zbigniew Bartuzi
Dec 1, 2015·Pharmacology & Therapeutics·Heleen H Van AckerViggo F Van Tendeloo
Jan 7, 2016·Cancer Research·Thomas R CoxJanine T Erler
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Nov 3, 2016·Maturitas·Florence A TrémollieresMargaret Rees
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 4, 2017·Therapeutic Advances in Musculoskeletal Disease·Bente LangdahlDavid W Dempster
Jun 7, 2017·Oncology Reviews·Filipa MacedoFrancisco Goncalves

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE9014
GSE2603
GSE43811

Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Pro Plus
Image

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Musculoskeletal & Neuronal Interactions
Theresa A Guise
The New England Journal of Medicine
Klaus Ley
© 2022 Meta ULC. All rights reserved