Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies

Journal of Agricultural and Food Chemistry
Maria Concetta GidaroStefano Alcaro

Abstract

The purpose of this work was to determine the kaempferol content in three red wines of Calabria, a southern Italian region with a great number of certified food products. Considering that wine cultivar, climate, and soil influence the qualitative and quantitative composition in flavonoids of Vitis vinifera L. berries, the three analyzed samples were taken from the 2013 vintage. Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination (DOC), were also investigated in the production of years 2008, 2010, and 2011. In addition to the analysis of kaempferol, which is present in higher concentration than in other Italian wines, in vitro assays were performed to evaluate, for the first time, the inhibition of the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition studies were also carried out to provide insight into the binding mode of kaempferol and selectivity of inhibition of the hMAO-A isoform.

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Citations

May 5, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Gokhan ZenginMarcello Locatelli
Jun 9, 2016·Journal of Agricultural and Food Chemistry·Giosuè CostaStefano Alcaro
Jan 13, 2018·Expert Opinion on Therapeutic Patents·Simone CarradoriJacques P Petzer
Jul 2, 2019·Central Nervous System Agents in Medicinal Chemistry·Idalet EngelbrechtAnél Petzer
Jan 7, 2020·Current Neuropharmacology·Elzbieta RebasLudmila Zylinska
Feb 28, 2019·BioMed Research International·Zhenxian ZhangPhillip M Gerk
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Priyanka DhimanAnurag Khatkar
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabián Olazarán-SantibañezEder Arredondo-Espinoza
Feb 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabella RomeoStefano Alcaro
May 28, 2021·Phytotherapy Research : PTR·Atefeh JalaliMohammad M Zarshenas
Sep 2, 2020·Journal of Agricultural and Food Chemistry·Se Eun ParkJae Sue Choi
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Simone CarradoriJacobus P Petzer
Jun 15, 2018·Journal of Agricultural and Food Chemistry·Huafang DingGuowen Zhang

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