Kainate-evoked changes in dystrophin messenger RNA levels in the rat hippocampus

Neuroscience
D C GóreckiL Kaczmarek

Abstract

Dystrophin and dystroglycan messenger RNAs are expressed in specific brain areas, including regions of the cortex and the hippocampus, and in such neurons dystrophin has been localized to postsynaptic densities. In the present study we examined by in situ hybridization the effect of neuronal activation and neurotoxicity induced by kainate and pentylenetetrazole administered in vivo on dystrophin and dystroglycan expression in the rat brain. Kainate injection resulted in a transient but dramatic decrease in dystrophin transcript levels in the dentate gyrus granule cells, neurons not affected by kainate neurotoxicity, 6 h after injection. There was also a strong, concomitant increase in dystrophin messenger RNA levels in the CA3 subfield. At 24-72 h after kainate injection, the dystrophin transcript in the dentate granule cells returned to control levels, while it decreased gradually in the CA subfields, coinciding with the neurodegeneration observed in these areas. Comparable results were obtained with pan-dystrophin probes and probes specific to the short, G-dystrophin (Dp71) isoform that predominates in the dentate gyrus. This indicates that any dystrophin transcript that might be expressed in these areas responds to kainate i...Continue Reading

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Citations

Feb 16, 2010·Journal of Natural Medicines·Fengling PuMichihiro Fujiwara
Mar 15, 2001·Neurochemistry International·S Zagulska-SzymczakL Kaczmarek
Sep 30, 1998·The European Journal of Neuroscience·L Danober, H C Pape
Oct 18, 2011·The Clinical Neuropsychologist·Giovanni MentoPatrizia S Bisiacchi
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Caroline Perronnet, Cyrille Vaillend
Feb 14, 2015·Neuroscience and Biobehavioral Reviews·Ruben G F HendriksenMarlien W Aalbers
Jul 17, 1999·Molecular and Cellular Neurosciences·D C GóreckiJ P Simons
Jul 28, 2016·Frontiers in Cellular Neuroscience·Ruben G F HendriksenJohan S H Vles
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May 18, 2005·Neurochemical Research·Roque Galaz-VegaArturo Ortega
Oct 31, 2018·Journal of the International Neuropsychological Society : JINS·Robert J FeeVeronica J Hinton
Apr 12, 2007·The Journal of Biological Chemistry·Piotr MichalukLeszek Kaczmarek
Nov 23, 2011·Molecular Neurobiology·Ramin TadayoniBulmaro Cisneros
May 23, 2000·Journal of Neurochemistry·J D FeldmanH R Herschman

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