Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets

Stroke; a Journal of Cerebral Circulation
F BariD W Busija

Abstract

Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is drastically reduced by anoxic stress. The effects of anoxic stress on cerebrovascular dilation to activation of other types of glutamate receptors are unknown. The purpose of this study was to examine the effects of ischemia on cerebral arteriolar responses to kainate in anesthetized piglets. Arteriolar responses to 5 x 10(-5) mol/L and 10(-4) mol/L kainate were evaluated before and 10 minutes after total, global ischemia. Ischemia was induced by increasing intracranial pressure. We measured pial arteriolar diameters (approximately 100 microns) using a cranial window and intravital microscopy. Before ischemia, kainate dilated arterioles by 16 +/- 2% at 5 x 10% mol/L and 30 +/- 2% at 10(-4) mol/L (mean +/- SEM; n = 6). After ischemia, the diameter of arterioles increased by 17 +/- 3% and 26 +/- 3% to 5 x 10% and 10(-4) mol/L kainate, respectively (P > .05). We also investigated the mechanisms involved in mediating arteriolar dilation to kainate. Intravenous administration of N omega-nitro-L-arginine methyl ester (L-NAME) (15 mg/kg) (n = 7) or indomethacin (10 mg/kg) (n = 6) individually reduced arteriolar dilation to kainate by approximately one half. Coadministratio...Continue Reading

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Citations

Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F BariD W Busija
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Hong SunWilliam G Mayhan
Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helena ParfenovaCharles W Leffler
Jan 4, 2006·Brain Research·Ferenc BariFerenc Domoki
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ferenc DomokiFerenc Bari
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zsombor LaczaDavid W Busija

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