Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.

Cell Reports
Alice PolenghiAndrea Barberis

Abstract

Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conformational states induced by glutamate binding on KAR lateral mobility at synapses. We report that following glutamate binding, KARs are readily and reversibly trapped at glutamatergic synapses through increased interaction with the β-catenin/N-cadherin complex. We demonstrate that such activation-dependent synaptic immobilization of KARs is crucial for the modulation of short-term plasticity of glutamatergic synapses. Thus, the present study unveils the crosstalk between conformational states and lateral mobility of KARs, a mechanism regulating glutamatergic signaling, particularly in conditions of sustained synaptic activity.

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Citations

Jan 28, 2021·Micromachines·Csaba ForroGabriella Panuccio
Mar 14, 2021·Nature Reviews. Neuroscience·Daniel ChoquetJean-Baptiste Sibarita
Mar 24, 2021·Chemical Reviews·Christian WernerChristian Geis
Apr 2, 2021·Neuropharmacology·Jithin D NairJack R Mellor
Apr 29, 2021·Neuropharmacology·Sari E LauriTomi Taira
Dec 14, 2021·Frontiers in Synaptic Neuroscience·Alexander KuhlemannChristian Werner

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Methods Mentioned

BETA
transfection
coimmunoprecipitation
immunoprecipitation
co-IP
X-ray
Protein Assay

Software Mentioned

MATLAB
Metamorph
Clampex
Clampfit
UGA32
ImageJ
Prism
Python
MIA

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