PMID: 6745322May 1, 1984

Kainic acid-induced denervation supersensitivity of nicotinic, cholinergic receptors in ganglion cells of the rat retina

Experimental Eye Research
D A RedburnF Samson

Abstract

The rat retina contains both nicotinic and muscarinic cholinergic receptor sites as demonstrated by specific, high affinity binding of the nicotinic ligand, [3H]-alpha-bungarotoxin, and the muscarinic ligand, [3H]-quinuclidinyl benzylate. Seven days after an intraocular injection of 5 nmol of kainic acid, nicotinic binding was increased three-fold. We suggest that nicotinic sites may be located on ganglion cells because previous studies have shown that many ganglion cells are spared after kainic acid treatment and in fact, have an increased physiological response to ACh under these conditions. The increase in nicotinic sites may reflect a supersensitivity response to the loss of acetylcholine input after the kainic acid lesion. In contrast, muscarinic binding was decreased by 70% after kainic acid treatment. These data suggest that muscarinic sites are located on amacrine cells since these cells are destroyed by kainic acid treatment and some are known to be cholino-receptive. Some of the retinal muscarinic sites may function as inhibitory autoreceptors which regulate acetylcholine release from cholinergic amacrine cells.

References

Jul 1, 1987·Experimental Eye Research·J B Hutchins
Mar 1, 1985·Journal of Neurochemistry·P Gomez-RamosC Pérez-Rico
Dec 15, 1989·The Journal of Comparative Neurology·E Townes-Anderson, B A Vogt

Citations

Oct 1, 1979·The Journal of Cell Biology·R M Masland, J W Mills
Jan 1, 1978·Progress in Neurobiology·E Heilbronn, T Bartfai
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H SugiyamaM Nirenberg
Jan 22, 1979·Life Sciences·J V Nadler
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·N SchechterJ Schmidt
Mar 1, 1976·Journal of Neurochemistry·C D Ross, D B McDougal
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Z Vogel, M Nirenberg
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Feb 1, 1971·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E RealeM Spitznas
Nov 1, 1981·Journal of Neurochemistry·P Gomez-RamosF Samson
Jan 1, 1981·Journal of Neuroscience Research·C K HamptonD A Redburn
Oct 1, 1980·Science·S A HaydenR M Masland

Related Concepts

Quinuclidinyl Benzilate
August Rats
Pyrrolidines
Cholinergic Receptors
Retina
Retinal Ganglion Cells
Nicotinic Receptors
kappa-Bungarotoxin
Acetylcholine Sulfate (1: 1)
Kainate

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