Kainic acid-induced dorsal and ventral hippocampal seizures in rats

Brain Research
K AkaikeM Takigawa

Abstract

Despite reports of differing regional seizure susceptibility in the hippocampus, hippocampal initiation of limbic seizures has not been precisely localized. We compared seizures induced by kainic acid microinjection into the left dorsal and ventral hippocampus of rats. Discharges following ventral injections rapidly propagated to the left amygdala and sensorimotor cortex unlike seizures following dorsal injections. The ventral group showed various ictal behaviors including motor manifestations, while dorsally injected rats showed only immobilization.

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Citations

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·D S Lebedev, V I Arkhipov
Jan 25, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vinogran NaidooBen A Bahr
Aug 24, 2002·Psychiatry and Clinical Neurosciences·Shen-ichiro FukumotoMorikuni Takigawa
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anatol BraginJerome Engel
Jul 14, 2009·Neurotoxicology·Vassiliki Aroniadou-AnderjaskaMaria F M Braga
May 6, 2009·Chemico-biological Interactions·Alfonso Alfaro-RodríguezNorma Labra-Ruiz
May 31, 2008·Brain Research·Ioannis LiagkourasGeorgios C Papadopoulos
May 20, 2003·Pharmacology & Toxicology·Laura Osorio-RicoCamilo Ríos
Nov 5, 2013·Neuroscience and Biobehavioral Reviews·Maxime Lévesque, Massimo Avoli
Mar 30, 2007·Seizure : the Journal of the British Epilepsy Association·Maria Leonor López-MerazLuisa Rocha
Jan 25, 2018·Scientific Reports·Lin LiAnatol Bragin
May 1, 2021·International Journal of Molecular Sciences·Michaela Shishmanova-DosevaJana Tchekalarova

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