Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts

Evidence-based Complementary and Alternative Medicine : ECAM
Nur Shafika Mohd SairaziSiti Amrah Sulaiman

Abstract

Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS). In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA). KA-induced excitotoxicity in rodent models has been shown to result in seizures, behavioral changes, oxidative stress, glial activation, inflammatory mediator production, endoplasmic reticulum stress, mitochondrial dysfunction, and selective neurodegeneration in the brain upon KA administration. Recently, there is an emerging trend to search for natural sources to combat against excitotoxicity-associated neurodegenerative diseases. Natural products and plant extracts had attracted a considerable amount of attention because of their reported beneficial effects on the CNS, particularly their neuroprotective effect against excitotoxicity. They provide significant reduction and/or protection against the development and progression of acute and chronic neurodegeneration. This indicates that natural products and plants extracts may be useful in protecting against excitotoxicity-associated neurodegeneration. Thus, targeting of multip...Continue Reading

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Citations

Aug 16, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·P Hemachandra ReddyChandra Sekhar Kuruva
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·P Hemachandra ReddyArubala P Reddy
Jun 9, 2020·Molecular Neurobiology·Alice Grison, Suzana Atanasoski
Oct 30, 2019·Nutrients·Maria Concetta ScutoVittorio Calabrese

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