Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Bioorganic & Medicinal Chemistry Letters
Fumiaki NakamuraYoichi Nakao

Abstract

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

Citations

Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jun 2, 2020·Frontiers in Chemistry·Meng ZhaoTao Ye
Jul 12, 2020·European Journal of Medicinal Chemistry·Jianzhou XuLijian Ding

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