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Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice

Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Jun 22, 2016

Arne HerringKathy Keyvani

Abstract

Memory loss and increased anxiety are clinical hallmarks of Alzheimer's disease (AD). Kallikrein-8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up-regulated in AD-affected human hippocampus. Therefore, an involvement of Kallikrein-8 in Alzheime...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Blood - Brain Barrier Anatomy
Memory Loss
Pathogenesis
Amnesia
APP protein, human
Post-Translational Protein Processing
Peptide Hydrolases
Brain
7
4
54
Paper Details
References
  • References41
  • Citations7
12345
  • References41
  • Citations7
1

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Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice

Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Jun 22, 2016

Arne HerringKathy Keyvani

PMID: 27327541

DOI: 10.1016/j.jalz.2016.05.006

Abstract

Memory loss and increased anxiety are clinical hallmarks of Alzheimer's disease (AD). Kallikrein-8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up-regulated in AD-affected human hippocampus. Therefore, an involvement of Kallikrein-8 in Alzheime...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Blood - Brain Barrier Anatomy
Memory Loss
Pathogenesis
Amnesia
APP protein, human
Post-Translational Protein Processing
Peptide Hydrolases
Brain
7
4
54

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

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Paper Details
References
  • References41
  • Citations7
12345
  • References41
  • Citations7
1
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