Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2

The Journal of Investigative Dermatology
Mari KishibeShigetaka Yoshida

Abstract

Kallikrein-related peptidase 8 (KLK8) is believed to be involved in the maintenance of skin homeostasis and pathogenesis of inflammatory skin diseases. Although previous studies have shown that KLK8 is expressed around incisional wounds, the exact role of KLK8 in wound healing remains obscure. In the present study, we compared wound healing in wild-type (WT) and Klk8 gene-disrupted (kallikrein-related peptidase 8 knockout, Klk8(-/-)) mouse skin. Wound healing in Klk8(-/-) mice was hampered with defective keratinocyte proliferation, differentiation, and migration in the early stages of wound healing. Compared with the prominent induction of Klk6 and protease-activated receptor 2 (PAR2) messenger RNA, and protein in WT mice after wounding, a much lower increase was observed in Klk8(-/-) skin. After skin wounding in WT mice, increased Klk6 was detected from the upper stratum spinosum to the stratum corneum. Moreover, in WT mice, Klk6 protein was processed. PAR2 was diffusely expressed in the cytoplasm of the stratum spinosum at day 7 post wounding in WT mice. These results suggest that Klk8 is involved in the proliferation and migration of keratinocytes through the upregulation and activation of Klk6 in the early stages of wound h...Continue Reading

References

Jun 5, 1998·The American Journal of Physiology·O DéryN W Bunnett
Apr 10, 1999·Brain Research·K TomizawaS Yoshida
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Apr 25, 2000·Cytogenetics and Cell Genetics·S YoshidaS Shiosaka
Sep 28, 2000·Biochemical and Biophysical Research Communications·G M YousefE P Diamandis
Mar 29, 2001·Molecular and Cellular Neurosciences·A HirataS Shiosaka
Mar 27, 2004·Physiological Reviews·Valeria S Ossovskaya, Nigel W Bunnett
May 14, 2004·The Journal of Investigative Dermatology·Akemi Ishida-YamamotoHajime Iizuka
Jan 19, 2005·The Journal of Investigative Dermatology·Maria BrattsandTorbjörn Egelrud
Feb 2, 2006·The Journal of Cell Biology·Xuan WangElaine Fuchs
Feb 4, 2006·The Journal of Investigative Dermatology·Nahoko KomatsuEleftherios P Diamandis
May 13, 2006·The Journal of Investigative Dermatology·Jean-Pierre HachemPeter M Elias
Aug 4, 2006·The Journal of Biological Chemistry·Katerina OikonomopoulouMorley D Hollenberg
Dec 13, 2006·The Journal of Biological Chemistry·Carla A BorgoñoEleftherios P Diamandis
Dec 22, 2006·The Journal of Biological Chemistry·Mari KishibeShigetaka Yoshida
May 24, 2007·Experimental Dermatology·Nahoko KomatsuEleftherios P Diamandis
Jul 13, 2007·The Journal of Investigative Dermatology·Kristina StefanssonTorbjörn Egelrud
Jul 17, 2008·Biological Chemistry·Azza Eissa, Eleftherios P Diamandis
May 27, 2010·The British Journal of Dermatology·K ShingakiM Tohyama
Aug 13, 2010·The Journal of Investigative Dermatology·Anaïs BriotAlain Hovnanian
Dec 28, 2010·Journal of Dermatological Science·Truus RoelandtJean-Pierre Hachem

❮ Previous
Next ❯

Citations

Oct 30, 2014·Molecular & Cellular Proteomics : MCP·Kathleen C LundbergNicole L Ward
Feb 24, 2015·Nature Reviews. Drug Discovery·Ioannis PrassasEleftherios P Diamandis
Jun 23, 2020·Critical Reviews in Clinical Laboratory Sciences·Caitlin T Di PaoloIoannis Prassas
Oct 1, 2019·The American Journal of Dermatopathology·Mizue FujiiAkemi Ishida-Yamamoto
Sep 11, 2019·Biochimie·Peter GoettigViktor Magdolen
Mar 27, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Pauline NauroyDimitra Kiritsi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.