Kallikrein-related peptidases are activators of the CC chemokine CCL14

European Journal of Immunology
Mario GrünbergH J Mägert

Abstract

Chemokine CCL14 is inactive in its proform. Here, we show that inflammation- and cancer-associated kallikrein-related peptidases KLK5 and KLK8 remove the N-terminal eight amino acids from the proform thereby converting CCL14 to its active state. Activity of the chemokine is demonstrated by migration of myeloid cells expressing relevant receptors.

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Citations

Nov 14, 2020·International Journal of Molecular Sciences·Jan KorbeckiIrena Baranowska-Bosiacka

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