PMID: 7440428Oct 1, 1980

Kanamycin ototoxicity and pigmentation in the guinea pig

Hearing Research
S D Comis, G Leng

Abstract

Cochleas from albino and pigmented guinea pigs were examined histologically following chronic administration of Kanamycin. In pigmented animals, damage was concentrated amongst hair cells towards the base, but in albinos, hair cell damage was diffusely spread. These observations support suggestions that melanin is implicated in Kanamycin ototoxicity.

References

Jul 1, 1989·American Journal of Otolaryngology·A R BeaubienA St Pierre
Feb 1, 1984·Hearing Research·G R Bock, K P Steel
Jan 1, 1985·Hearing Research·L C ShaddockC G Wright
Aug 15, 1990·Hearing Research·D McAlpine, B M Johnstone
Mar 1, 1995·Hearing Research·A R BeaubienE Ormsby
May 1, 1991·Neurotoxicology and Teratology·W J Clerici, L D Fechter
Dec 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R AbeleY Kenis
Nov 1, 1985·British Journal of Audiology·P W Collins, J M Twine
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·E J LienL L Lien
Mar 1, 1994·Audiology : Official Organ of the International Society of Audiology·M D SzymanskiF O Buchting

Citations

Jan 1, 1974·Audiology : Official Organ of the International Society of Audiology·S Crifò
Jan 1, 1974·Audiology : Official Organ of the International Society of Audiology·P Dallos, C Y Wang

Related Concepts

Albinism
Cavia
Kantrex
Melanins
46, XY Sex Reversal 5
Skin Pigmentation
Kanamycin
Cavia porcellus
Cochlear Structure
Auditory Hair Cell

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