Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine : ECAM
Siqi HuangSifang Zhang

Abstract

To systematically review whether the Kangai injection (KAI), which is commonly used traditional Chinese medicine, can improve the clinical efficacy of chemotherapy and relieve adverse reactions of chemotherapy in advanced colorectal cancer (CRC) patients. A comprehensive literature search was performed in three English and three Chinese electronic databases until March 2019. The literature was screened by EndNote X8 and data were analysed by RevMan5 and Stata12.0. This meta-analysis consisted of twenty-eight studies, of which 2310 cases were reported. Among the 2310 cases, 1207 cases were treated with KAI combined with chemotherapy and 1103 cases were treated with chemotherapy alone. The results showed that KAI combined with chemotherapy significantly improved tumor response (Risk Ratio (RR) =1.32; 95% confidence interval (CI): 1.22-1.43; p<0.00001); Karnofsky performance status (KPS score) (Risk Ratio (RR) =1.48; 95% CI: 1.36-1.60; p<0.00001); reduced adverse drug reactions (ADRs) such as nausea and vomiting (OR =0.31; 95% CI: 0.24-0.41; p <0.00001), diarrhea (OR =0.36; 95% CI: 0.25-0.52; p<0.00001), leukopenia (OR =2.97; 95% CI:2.27-3.88; p<0.00001), thrombocytopenia (OR =0.53; 95% CI: 0.38-0.74; p<0.0002), liver dysfunction ...Continue Reading

References

May 31, 2008·Techniques in Coloproctology·K Y TanF Seow-Choen
Apr 16, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Yueh-Hsiang LiaoTsai-Chung Li
Jun 10, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Z SunR C Zhao
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jan 1, 2015·Nature Reviews. Disease Primers·Ernst J KuipersToshiaki Watanabe
Jul 9, 2016·Chinese Journal of Integrative Medicine·Feng-Xia LinSi-Fang Zhang
Nov 1, 2016·Digestive Diseases and Sciences·Jinzhou ZhuYouming Li
Jan 13, 2017·Current Medicinal Chemistry·Rachel M McQuadeKulmira Nurgali
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 10, 2017·Current Treatment Options in Oncology·Louise C ConnellPaulo M Hoff
Jun 18, 2017·Cancer Biotherapy & Radiopharmaceuticals·Fang GengBangwei Cao
Apr 6, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Shaofan ZhangSifang Zhang
Apr 18, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dan MaoSifang Zhang

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Software Mentioned

RevMan
Stata12
EndNote
VIP

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