Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain

Journal of Ethnopharmacology
Qi ZhaoKinzo Matsumoto

Abstract

Kangen-karyu (KK) is a traditional Chinese prescription consisting of six different herbs. This study was conducted to investigate the anti-dementia effect of KK on aging-induced cognitive deficits and the underlying mechanism using senescence-accelerated mice prone (SAMP8). Twenty-week old SAMP8 (older SAMP8) were used as an animal model of aging and age-matched senescence-resistant inbred strain (SAMR1) and 8-week-old SAMP8 (young SAMP8) were as controls. Older SAMP8 received daily administration of KK (100 mg/kg, p.o.) or water vehicle for 22 days. Compared to the controls, older SAMP8 exhibited cognitive deficits in the object recognition and object location tests; however, KK improved the deficits caused by aging. Moreover, the older SAMP8 treated with vehicle exhibited reduced anxiety-like behavior in the elevated plus-maze test compared to SAMR1, but KK had no effect on emotional disorder of older SAMP8. The levels of biochemical factors related to neuro-plasticity and learning and memory; i.e., phosphorylated forms of N-methyl-D-aspartate receptor 1, Ca(2+)/calmodulin-dependent protein kinase II, and cyclic AMP-responsive element-binding protein, and brain-derived neurotrophic factor, were significantly decreased in old...Continue Reading

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Citations

Jun 4, 2016·Journal of Clinical Biochemistry and Nutrition·Aki HirayamaKazumasa Aoyagi
Jul 26, 2013·Journal of Pharmacological Sciences·Kinzo MatsumotoJun-Ichiro Oka
Apr 26, 2011·Journal of Ethnopharmacology·Marina YamadaKinzo Matsumoto
May 8, 2020·Drug Discoveries & Therapeutics·Chan Hum ParkTakako Yokozawa
Nov 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pradeep PaudelJae Sue Choi
Mar 3, 2020·Drug Discoveries & Therapeutics·Tsutomu KitazawaTakako Yokozawa
Mar 14, 2021·Translational Stroke Research·Xuejing ZhangJane Q Wang

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