Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells

Oncotarget
Guiling ShiFei Xing

Abstract

Tumor necrosis factor-alpha is a critical pro-inflammatory cytokine produced by macrophages and was once considered an anti-tumor agent. However, a low dose of tumor necrosis factor-alpha can cause epithelial mesenchymal transition, angiogenesis and metastasis. NF-κΒ contributes to epithelial mesenchymal transition induced by tumor necrosis factor-alpha. Kanglaite, an extract from the Coix lacryma-jobi (adlay) seed, is an NF-κΒ inhibitor. The aim of this study was to investigate whether Kanglaite could inhibit epithelial mesenchymal transition caused by tumor necrosis factor-alpha using four colorectal cancer cell lines, HCT106, HCT116, LoVo and CT26. Our results showed that tumor necrosis factor-alpha -mediated activation of NF-κΒ, caused changes in epithelial mesenchymal transition -related protein expression, and increased migration and invasion in all four cell lines. However, these effects were inhibited by Kanglaite when used in combination with tumor necrosis factor-alpha. In a subcutaneous tumor model of CT26, tumor necrosis factor-alpha enhanced the tumorigenic ability of the cells, and again this was inhibited by Kanglaite. However, treatment with Kanglaite alone caused almost no inhibition of epithelial mesenchymal t...Continue Reading

References

May 1, 1993·The Journal of Clinical Investigation·M S NaylorF R Balkwill
Mar 20, 2002·Cytokine & Growth Factor Reviews·Fran Balkwill
Mar 26, 2003·Cell Death and Differentiation·H WajantP Scheurich
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Aug 23, 2008·Journal of Experimental & Clinical Cancer Research : CR·Yun LuQian Dong
Oct 29, 2008·Acta Pharmacologica Sinica·Xia Wang, Yong Lin
Apr 4, 2009·Nature Reviews. Cancer·Frances Balkwill
May 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiang ZhangChung Lee
Jul 17, 2009·Journal of Cellular and Molecular Medicine·Laura RamudoIsabel De Dios
Jan 21, 2010·British Journal of Cancer·Y Wu, B P Zhou
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyo-Jung KwonInpyo Choi
May 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aristeidis G VaiopoulosAthanasios G Papavassiliou
May 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Supachai YodkeereePornngarm Limtrakul
Oct 31, 2016·Journal of Cellular Physiology·Vermont P Dia, Philipus Pangloli

❮ Previous
Next ❯

Citations

Oct 17, 2019·BMC Complementary and Alternative Medicine·Huiquan LiuShiying Yu
Jul 30, 2020·Cytokine·Soroush NajdaghiNima Rezaei
Jul 3, 2021·PLoS Computational Biology·Alexis M ThorntonAngela N Brooks

❮ Previous
Next ❯

Software Mentioned

SPSS
Quantity One

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.